Personal profile
University web profile link
Research interests
- aneuploidy and chromosomal instability
- stress signalling
- (ovarian) cancer biology
I focus on investigating the role of JNK stress signalling in cancer progression, metastasis, and therapeutic resistance, as well as its potential as a therapeutic target. The JNK pathway has dual, context-dependent roles, exhibiting both pro- and anti-tumorigenic effects, which are thought to depend on the cell type involved. I believe that unravelling the complexities of JNK signalling is one of the challenges in cancer research today.
Related documents
Education/Academic qualification
Recognised by Advance HE as an Associate Fellow against Descriptor 1 of the UKPSF
Doctorate
Recognised by Advance HE as a Fellow against Descriptor 2 of the UKPSF
External positions
Postdoctoral Researcher, The Francis Crick Institute Limited
5 Jan 2020 → 1 Dec 2024
PhD Candidate, Hubrecht Institute
1 Sept 2014 → 31 Oct 2019
Keywords
- Q Science (General)
- QP Physiology
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Collaborations and top research areas from the last five years
Projects
- 1 Finished
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Predicting CIN rates from single-cell whole genome sequencing data using an in silico model
Bakker, B., Schubert, M., Bolhaqueiro, A. C. F., Kops, G. J. P. L., Spierings, D. C. J. & Foijer, F., 15 Feb 2023, bioRxiv.Research output: Working paper › Preprint
Open Access -
Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns
Bollen, Y., Stelloo, E., van Leenen, P., van den Bos, M., Ponsioen, B., Lu, B., van Roosmalen, M. J., Kimberley, C., Bolhaqueiro, A. C. F., Mossner, M., Cross, W. C. H., Besselink, N. J. M., van der Roest, B., Boymans, S., Oost, K. C., de Vries, S. G., Rehmann, H., Cuppen, E., Lens, S. M. A. & Kops, G. J. P. L. & 6 others, , Aug 2021, In: Nature Genetics. 53, 8, p. 1187-1195 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A biosensor for the mitotic kinase MPS1 reveals spatiotemporal activity dynamics and regulation
Kuijt, T. E. F., Lambers, M. L. A., Weterings, S., Ponsioen, B., Bolhaqueiro, A. C. F., Staijen, D. H. M. & Kops, G. J. P. L., 5 Oct 2020, In: Current Biology. 30, 19, p. 3862-3870 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
Bolhaqueiro, A. C. F., Ponsioen, B., Bakker, B., Klaasen, S. J., Kucukkose, E., van Jaarsveld, R. H., Vivié, J., Verlaan-Klink, I., Hami, N., Spierings, D. C. J., Sasaki, N., Dutta, D., Boj, S. F., Vries, R. G. J., Lansdorp, P. M., van de Wetering, M., van Oudenaarden, A., Clevers, H., Kranenburg, O. & Foijer, F. & 2 others, , May 2019, In: Nature Genetics. 51, 5, p. 824-834 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Live imaging of cell division in 3D stem-cell organoid cultures
Bolhaqueiro, A. C. F., van Jaarsveld, R. H., Ponsioen, B., Overmeer, R. M., Snippert, H. J. & Kops, G. J. P. L., 27 Jun 2018, Mitosis and Meiosis Part B. Maiato, H. & Schuh, M. (eds.). London, U.K.: Academic Press Inc., p. 91-106 16 p. (Methods in Cell Biology; vol. 145).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review