5.5ÔÇàSuccessful insilico discovery of novel hypoxia regulated genes in pre-eclampsia.

Vijaya Karanam; Nick Anim-Nyame; Nigel Page

doi:10.1136/archdischild-2014-306576.14

5.5ÔÇàSuccessful insilico discovery of novel hypoxia regulated genes in pre-eclampsia.

Vijaya Karanam
, Nick Anim-Nyame
, Nigel Page

Research output: Contribution to conference › Lecture / Speech › peer-review

Abstract

DDD identified a total of 32 gene clusters to be differentially expressed and six of them were found to be hypoxia regulated. Angiogenin inhibitor, apolipoprotein E, NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 (NDUFAB1) and round about homolog 4 (ROBO4) were the upregulated genes and H19 and growth differentiating factor (GDF15) were the down regulated genes. Rt-QPCR studies showed similar results thus providing a proof that insilico techniques can be used as tools for novel gene discovery in gestational diseases like pre-eclampsia.

Original language	English
DOIs	https://doi.org/10.1136/archdischild-2014-306576.14
Publication status	Published - Jun 2014
Event	Perinatal Medicine 2014 - Harrogate, U.K. Duration: 9 Jun 2014 → 11 Jun 2014

Conference

Conference	Perinatal Medicine 2014
Period	9/06/14 → 11/06/14

Keywords

Allied health professions and studies

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10.1136/archdischild-2014-306576.14

http://dx.doi.org/10.1136/archdischild-2014-306576.14

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title = "5.5{\^O}{\c C}{\`a}Successful insilico discovery of novel hypoxia regulated genes in pre-eclampsia.",

abstract = "DDD identified a total of 32 gene clusters to be differentially expressed and six of them were found to be hypoxia regulated. Angiogenin inhibitor, apolipoprotein E, NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 (NDUFAB1) and round about homolog 4 (ROBO4) were the upregulated genes and H19 and growth differentiating factor (GDF15) were the down regulated genes. Rt-QPCR studies showed similar results thus providing a proof that insilico techniques can be used as tools for novel gene discovery in gestational diseases like pre-eclampsia.",

keywords = "Allied health professions and studies",

author = "Vijaya Karanam and Nick Anim-Nyame and Nigel Page",

year = "2014",

month = jun,

doi = "10.1136/archdischild-2014-306576.14",

language = "English",

note = "Perinatal Medicine 2014 ; Conference date: 09-06-2014 Through 11-06-2014",

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T1 - 5.5ÔÇàSuccessful insilico discovery of novel hypoxia regulated genes in pre-eclampsia.

AU - Karanam, Vijaya

AU - Anim-Nyame, Nick

AU - Page, Nigel

PY - 2014/6

Y1 - 2014/6

N2 - DDD identified a total of 32 gene clusters to be differentially expressed and six of them were found to be hypoxia regulated. Angiogenin inhibitor, apolipoprotein E, NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 (NDUFAB1) and round about homolog 4 (ROBO4) were the upregulated genes and H19 and growth differentiating factor (GDF15) were the down regulated genes. Rt-QPCR studies showed similar results thus providing a proof that insilico techniques can be used as tools for novel gene discovery in gestational diseases like pre-eclampsia.

AB - DDD identified a total of 32 gene clusters to be differentially expressed and six of them were found to be hypoxia regulated. Angiogenin inhibitor, apolipoprotein E, NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1 (NDUFAB1) and round about homolog 4 (ROBO4) were the upregulated genes and H19 and growth differentiating factor (GDF15) were the down regulated genes. Rt-QPCR studies showed similar results thus providing a proof that insilico techniques can be used as tools for novel gene discovery in gestational diseases like pre-eclampsia.

KW - Allied health professions and studies

U2 - 10.1136/archdischild-2014-306576.14

DO - 10.1136/archdischild-2014-306576.14

M3 - Lecture / Speech

C2 - 25021265

T2 - Perinatal Medicine 2014

Y2 - 9 June 2014 through 11 June 2014

ER -

5.5ÔÇàSuccessful insilico discovery of novel hypoxia regulated genes in pre-eclampsia.

Abstract

Conference

Keywords

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