Abstract
High-field proton NMR spectroscopic analysis of urine and plasma has been employed to study the biochemical effects and nephrotoxic action of an intramuscular dose of auranofin in rats. Auranofin induced a characteristic profile of proximal tubular damage as evidenced by aminoaciduria, lactic aciduria and increased urinary acetate concentrations. In addition, ethanol was detectable in both urine and plasma obtained from auranofin-treated rats. Auranofin-mediated elevations in the plasma and urine concentrations of 3-D-hydroxybutyrate indicated an increased utilisation of fats for fuel in rats treated with this novel therapeutic agent.
| Original language | English |
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| Publication status | Published - 1991 |
| Event | Satellite Symp Of The 9th International Congress Of Pharmacology : Drugs In Inflammation - Noordwijk, Netherlands Duration: 28 Jun 1990 → 29 Jun 1990 |
Conference
| Conference | Satellite Symp Of The 9th International Congress Of Pharmacology : Drugs In Inflammation |
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| Period | 28/06/90 → 29/06/90 |
Keywords
- Allied health professions and studies