Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Hamdy Abdelkader; Raid G. Alany; Barbara Pierscionek

doi:10.1111/jphp.12355

Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Hamdy Abdelkader, Raid G. Alany, Barbara Pierscionek

Research output: Contribution to journal › Article › peer-review

Abstract

This review discusses the anatomy and physiology of the lens and the changes that are understood to occur with ageing and cataract formation to identify potential areas for effective therapeutic intervention. Experimental techniques and agents used to induce cataract in animal models, the advantages and disadvantages of potential pharmacological treatments specific barriers to delivery of exogenous antioxidants to the lens and the prospects for future research are discussed.

Original language	English
Pages (from-to)	537-550
Journal	Journal of Pharmacy and Pharmacology
Volume	67
Issue number	4
DOIs	https://doi.org/10.1111/jphp.12355
Publication status	Published - Apr 2015

Bibliographical note

Note: This work was supported by the Leverhulme Trust; Research Fellowship Grant 2012

Keywords

antioxidants
aspirin
bendazac and naltrexone
carnosine
carotenoids
cataract
crystallins
flavonoids
ocular delivery
Pharmacy

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10.1111/jphp.12355

http://dx.doi.org/10.1111/jphp.12355

Cite this

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abstract = "This review discusses the anatomy and physiology of the lens and the changes that are understood to occur with ageing and cataract formation to identify potential areas for effective therapeutic intervention. Experimental techniques and agents used to induce cataract in animal models, the advantages and disadvantages of potential pharmacological treatments specific barriers to delivery of exogenous antioxidants to the lens and the prospects for future research are discussed.",

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AB - This review discusses the anatomy and physiology of the lens and the changes that are understood to occur with ageing and cataract formation to identify potential areas for effective therapeutic intervention. Experimental techniques and agents used to induce cataract in animal models, the advantages and disadvantages of potential pharmacological treatments specific barriers to delivery of exogenous antioxidants to the lens and the prospects for future research are discussed.

KW - antioxidants

KW - aspirin

KW - bendazac and naltrexone

KW - carnosine

KW - carotenoids

KW - cataract

KW - crystallins

KW - flavonoids

KW - ocular delivery

KW - Pharmacy

UR - http://www.ncbi.nlm.nih.gov/pubmed/25643848

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Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Abstract

Bibliographical note

Keywords

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