TY - JOUR
T1 - Associations with photoreceptor thickness measures in the UK Biobank
AU - UK Biobank Eye and Vision Consortium
AU - Chua, Sharon Y.L.
AU - Dhillon, Baljean
AU - Aslam, Tariq
AU - Balaskas, Konstantinos
AU - Yang, Qi
AU - Keane, Pearse A.
AU - Tufail, Adnan
AU - Reisman, Charles
AU - Foster, Paul J.
AU - Patel, Praveen J.
AU - Bishop, Prof Paul
AU - Barman, Prof Sarah A.
AU - Barrett, Prof Jenny H.
AU - Blows, Mr Peter
AU - Bunce, Dr Catey
AU - Carare, Dr Roxana O.
AU - Chakravarthy, Prof Usha
AU - Chan, Dr Michelle
AU - Crabb, Prof David P.
AU - Cumberland, Mrs Philippa M.
AU - Day, Dr Alexander
AU - Desai, Dr Parul
AU - Sudlow, Prof Cathie
AU - Dick, Prof Andrew D.
AU - Egan, Dr Cathy
AU - Ennis, Prof Sarah
AU - Fruttiger, Dr Marcus
AU - Gallacher, Dr John E.J.
AU - Garway-Heath, Prof David F.
AU - Gibson, Dr Jane
AU - Gore, Mr Dan
AU - Guggenheim, Prof Jeremy A.
AU - Hammond, Prof Chris J.
AU - Hardcastle, Prof Alison
AU - Harding, Prof Simon P.
AU - Hogg, Dr Ruth E.
AU - Hysi, Dr Pirro
AU - Khaw, Prof Sir Peng T.
AU - Khawaja, Dr Anthony P.
AU - Lascaratos, Dr Gerassimos
AU - Lotery, Prof Andrew J.
AU - Macgillivray, Dr Tom
AU - Mackie, Dr Sarah
AU - Martin, Prof Keith
AU - Mcgaughey, Ms Michelle
AU - Mcguinness, Dr Bernadette
AU - Mckay, Dr Gareth J.
AU - Mckibbin, Mr Martin
AU - Mitry, Dr Danny
AU - Moore, Prof Tony
N1 - Note: This work was supported by the National Institute for Health Research [Biomedical Research Centre and Clinician Scientist award (CS-2014-14-023)], UCL Institute of Ophthalmology, University College London, Eranda Foundation via International Glaucoma Association and the Richard Desmond Charitable Trust via Fight for Sight UK.
PY - 2019/12/19
Y1 - 2019/12/19
N2 - Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.
AB - Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40-69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.
KW - Other laboratory based clinical subjects
U2 - 10.1038/s41598-019-55484-1
DO - 10.1038/s41598-019-55484-1
M3 - Article
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
M1 - 19440
ER -