Abstract
S-(1-Oxido-2-pyridinyl)-1,1,3,3-tetramethylthiouronium hexafluorophosphate (HOTT) facilitates the first examples of efficient radical cyclisation with (hetero)aromatic substitution via Barton ester intermediates. Cyclopropyl and alkyl radicals allow access to five, six and seven-membered alicyclic-ring fused heterocycles with and without an additional fused cyclopropane, including the skeleton of the anti-cancer agent, cyclopropamitosene, expanded, and diazole analogues. Radical initiators are not required for cyclisation from carboxylic acid precursors.
| Original language | English |
|---|---|
| Article number | 1682 |
| Pages (from-to) | 1672 |
| Number of pages | 10 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 11 |
| Early online date | 23 Jan 2013 |
| DOIs | |
| Publication status | Published - 9 Nov 2013 |
| Externally published | Yes |