Combining Two-Directional Synthesis and Tandem Reactions, Part 8: A Novel Condensation/Michael Addition/Cycloaddition/Fragmentation/Lactamisation Cascade

Alex Sinclair; Louise Arini; Martin Rejzek; Peter Szeto; Robert Stockman

doi:10.1055/s-2006-949634

Combining Two-Directional Synthesis and Tandem Reactions, Part 8: A Novel Condensation/Michael Addition/Cycloaddition/Fragmentation/Lactamisation Cascade

Alex Sinclair, Louise Arini, Martin Rejzek, Peter Szeto, Robert Stockman

Research output: Contribution to journal › Article › peer-review

Abstract

A tandem oxime formation/Michael addition/1,4-prototopic shift/[3+2]-cycloaddition of an acyclic symmetrical precursor results in a tricyclic isooxazolidine which then undergoes a further fragmentation/lactamisation cascade to generate a non-symmetrical tricyclic a-ketolactam as a single diastereomer

Original language	English
Pages (from-to)	2321-2324
Journal	Synlett
Volume	2006
Issue number	14
DOIs	https://doi.org/10.1055/s-2006-949634
Publication status	Published - Sept 2006

Keywords

Chemistry

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http://dx.doi.org/10.1055/s-2006-949634

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title = "Combining Two-Directional Synthesis and Tandem Reactions, Part 8: A Novel Condensation/Michael Addition/Cycloaddition/Fragmentation/Lactamisation Cascade",

abstract = "A tandem oxime formation/Michael addition/1,4-prototopic shift/[3+2]-cycloaddition of an acyclic symmetrical precursor results in a tricyclic isooxazolidine which then undergoes a further fragmentation/lactamisation cascade to generate a non-symmetrical tricyclic a-ketolactam as a single diastereomer",

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AU - Rejzek, Martin

AU - Szeto, Peter

AU - Stockman, Robert

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AB - A tandem oxime formation/Michael addition/1,4-prototopic shift/[3+2]-cycloaddition of an acyclic symmetrical precursor results in a tricyclic isooxazolidine which then undergoes a further fragmentation/lactamisation cascade to generate a non-symmetrical tricyclic a-ketolactam as a single diastereomer

KW - Chemistry

U2 - 10.1055/s-2006-949634

DO - 10.1055/s-2006-949634

M3 - Article

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ER -

Combining Two-Directional Synthesis and Tandem Reactions, Part 8: A Novel Condensation/Michael Addition/Cycloaddition/Fragmentation/Lactamisation Cascade

Abstract

Keywords

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