Abstract
Small noncoding RNAs do not code for proteins, but have been shown to perform regulatory roles in the
cell, including the regulation of processes such as secretion and virulence. A small noncoding RNA,nrrF,
that mediates Fur-dependant regulation of succinate dehydrogenase has been previously identified in
Neisseria meningitidis. Deep sequencing of transcriptomes has revealed small noncoding RNAs in both
N. meningitidis and Neisseria gonorrheoae. A small noncoding RNA, Hfq found in N. meningitidis is
up-regulated during incubation in blood suggesting that noncoding RNAs might also play a role in
N. meningitidis infection. Analysis of differential expression in intergenic regions showed enhanced
transcription of a novel non-coding RNA molecule of 74 nucleotides, involved in the riboregulation of
target mRNAs. Research on Correia Repeat Enclosed Elements in the Neisseria spp. has shown that many
of them are 5‘ of genes and possess functional promoter elements. A comparison of available neisserial
genome sequences was undertaken to see if Correia Repeat Enclosed Elements were found at similar
positions to predicted and previously identified small noncoding RNAs. A high correlation between
the locations of small noncoding RNAs and Correia Repeat Enclosed Element was seen in some strains.
| Original language | English |
|---|---|
| Publication status | Published - 10 Sept 2012 |
| Event | XVIIIth International Pathogenic Neisseria Conference (IPNC) - W├╝rzburg, Germany Duration: 9 Sept 2012 → 14 Sept 2012 |
Conference
| Conference | XVIIIth International Pathogenic Neisseria Conference (IPNC) |
|---|---|
| Period | 9/09/12 → 14/09/12 |
Keywords
- Allied health professions and studies