Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES)

Sabbir Ahmed; Karen James

doi:10.1016/S0960-894X(99)00245-0

Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES)

Sabbir Ahmed
, Karen James

Research output: Contribution to journal › Article › peer-review

Abstract

We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

Original language	English
Pages (from-to)	1645-1650
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	12
DOIs	https://doi.org/10.1016/S0960-894X(99)00245-0
Publication status	Published - 21 Jun 1999

Keywords

steroid sulfatase
estrone-3-o-sulfamate
inhibitors
Chemistry

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10.1016/S0960-894X(99)00245-0

http://dx.doi.org/10.1016/S0960-894X(99)00245-0

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abstract = "We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.",

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AU - Ahmed, Sabbir

AU - James, Karen

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Y1 - 1999/6/21

N2 - We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

AB - We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

KW - steroid sulfatase

KW - estrone-3-o-sulfamate

KW - inhibitors

KW - Chemistry

UR - http://www.ncbi.nlm.nih.gov/pubmed/10397493

U2 - 10.1016/S0960-894X(99)00245-0

DO - 10.1016/S0960-894X(99)00245-0

M3 - Article

C2 - 10397493

SN - 0960-894X

VL - 9

SP - 1645

EP - 1650

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 12

ER -

Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES)

Abstract

Keywords

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