Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: Design and construction of a mutant with testosterone hydroxylase activity

Gillian Smith; Sandeep Modi; Ilona Pillai; Lu-Yun Lian; Michael J. Sutcliffe; Michael P. Pritchard; Thomas Freidberg; Gordon C.K. Roberts; Roland Wolf

doi:10.1042/bj3310783

Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: Design and construction of a mutant with testosterone hydroxylase activity

Gillian Smith
, Sandeep Modi
, Ilona Pillai
, Lu-Yun Lian
, Michael J. Sutcliffe
, Michael P. Pritchard
, Thomas Freidberg
, Gordon C.K. Roberts
, Roland Wolf

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	783-792
Journal	Biochemical Journal
Volume	331
Issue number	3
DOIs	https://doi.org/10.1042/bj3310783
Publication status	Published - 1 May 1998
Externally published	Yes

Keywords

Chemistry

Access to Document

10.1042/bj3310783

http://dx.doi.org/10.1042/bj3310783

Cite this

@article{5ef3eb6b72314f0a95e38652cdca879e,

title = "Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: Design and construction of a mutant with testosterone hydroxylase activity",

keywords = "Chemistry",

author = "Gillian Smith and Sandeep Modi and Ilona Pillai and Lu-Yun Lian and Sutcliffe, \{Michael J.\} and Pritchard, \{Michael P.\} and Thomas Freidberg and Roberts, \{Gordon C.K.\} and Roland Wolf",

year = "1998",

month = may,

day = "1",

doi = "10.1042/bj3310783",

language = "English",

volume = "331",

pages = "783--792",

journal = "Biochemical Journal",

issn = "0300-5127",

publisher = "Portland Press Ltd",

number = "3",

}

TY - JOUR

T1 - Determinants of the substrate specificity of human cytochrome P-450 CYP2D6

T2 - Design and construction of a mutant with testosterone hydroxylase activity

AU - Smith, Gillian

AU - Modi, Sandeep

AU - Pillai, Ilona

AU - Lian, Lu-Yun

AU - Sutcliffe, Michael J.

AU - Pritchard, Michael P.

AU - Freidberg, Thomas

AU - Roberts, Gordon C.K.

AU - Wolf, Roland

PY - 1998/5/1

Y1 - 1998/5/1

KW - Chemistry

U2 - 10.1042/bj3310783

DO - 10.1042/bj3310783

M3 - Article

SN - 0300-5127

VL - 331

SP - 783

EP - 792

JO - Biochemical Journal

JF - Biochemical Journal

IS - 3

ER -