Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism

Sabbir Ahmed; Karen James; Caroline P. Owen; Chirag K. Patel; Mijal B. Patel

doi:10.1016/S0960-894X(01)00607-2

Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism

Sabbir Ahmed, Karen James, Caroline P. Owen, Chirag K. Patel, Mijal B. Patel

Research output: Contribution to journal › Article › peer-review

Abstract

Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

Original language	English
Pages (from-to)	3001-3005
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(01)00607-2
Publication status	Published - 3 Dec 2001

Keywords

steroid sulfatase
inhibitors
estrone-3-o-sulfamate
Chemistry

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10.1016/S0960-894X(01)00607-2

http://dx.doi.org/10.1016/S0960-894X(01)00607-2

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title = "Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism",

abstract = "Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.",

keywords = "steroid sulfatase, inhibitors, estrone-3-o-sulfamate, Chemistry",

author = "Sabbir Ahmed and Karen James and Owen, \{Caroline P.\} and Patel, \{Chirag K.\} and Patel, \{Mijal B.\}",

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AU - Ahmed, Sabbir

AU - James, Karen

AU - Owen, Caroline P.

AU - Patel, Chirag K.

AU - Patel, Mijal B.

PY - 2001/12/3

Y1 - 2001/12/3

N2 - Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

AB - Using the postulated mechanism for the enzyme estrone sulfatase (ES), we have determined a possible transition state for the reaction catalysed by ES as a representation of the active site. Using the derived structure, we have undertaken the molecular modelling of several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors.

KW - steroid sulfatase

KW - inhibitors

KW - estrone-3-o-sulfamate

KW - Chemistry

UR - http://www.ncbi.nlm.nih.gov/pubmed/11714597

U2 - 10.1016/S0960-894X(01)00607-2

DO - 10.1016/S0960-894X(01)00607-2

M3 - Article

C2 - 11714597

SN - 0960-894X

VL - 11

SP - 3001

EP - 3005

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism

Abstract

Keywords

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