TY - JOUR
T1 - Determination of bromate in drinking water by ultraperformance liquid chromatography-tandem mass spectrometry
AU - Alsohaimi, Ibrahim Hotan
AU - Alothman, Zeid Abdullah
AU - Khan, Mohammad Rizwan
AU - Abdalla, Mohammad Abulhassan
AU - Busquets, Rosa
AU - Alomary, Ahmad Khodran
N1 - Note: This work was supported by a Deanship of Scientific Research, King Saud University, research group project (RGP-VPP-043).
PY - 2012/10
Y1 - 2012/10
N2 - Bromate is a byproduct formed as a result of disinfection of bromide-containing source water with ozone or hypochlorite. The International Agency for Research on Cancer has recognized bromate as a possible human carcinogen, thus it is essential to determine in drinking water. Present work highlights a development of sensitive and fast analytical method for bromate determination in drinking water by using ultraperformance liquid chromatography-tandem mass spectrometry. The quality parameters of the developed method were established, obtaining very low limit of detection (0.01 ng/mL), repeatability and reproducibility have been found to be less than 3% in terms of relative standard deviation when analyzing a bromate standard at 0.05 μg/mL with 0.4 min analysis time. Developed method was applied for the analysis of metropolitan and bottled water from Saudi Arabia; 22 samples have been analyzed. Bromate was detected in the metropolitan water samples (from desalinization source) at concentrations ranging between 3.43 and 75.04 ng/mL and in the bottled water samples at concentrations ranging between 2.07 and 21.90 ng/mL. Moreover, in comparison to established analytical methods such as liquid chromatography-tandem mass spectrometry, the proposed method was found to be very sensitive, selective and rapid for the routine analysis of bromate at low level in drinking water.
AB - Bromate is a byproduct formed as a result of disinfection of bromide-containing source water with ozone or hypochlorite. The International Agency for Research on Cancer has recognized bromate as a possible human carcinogen, thus it is essential to determine in drinking water. Present work highlights a development of sensitive and fast analytical method for bromate determination in drinking water by using ultraperformance liquid chromatography-tandem mass spectrometry. The quality parameters of the developed method were established, obtaining very low limit of detection (0.01 ng/mL), repeatability and reproducibility have been found to be less than 3% in terms of relative standard deviation when analyzing a bromate standard at 0.05 μg/mL with 0.4 min analysis time. Developed method was applied for the analysis of metropolitan and bottled water from Saudi Arabia; 22 samples have been analyzed. Bromate was detected in the metropolitan water samples (from desalinization source) at concentrations ranging between 3.43 and 75.04 ng/mL and in the bottled water samples at concentrations ranging between 2.07 and 21.90 ng/mL. Moreover, in comparison to established analytical methods such as liquid chromatography-tandem mass spectrometry, the proposed method was found to be very sensitive, selective and rapid for the routine analysis of bromate at low level in drinking water.
KW - Chemistry
UR - http://www.ncbi.nlm.nih.gov/pubmed/22815069
U2 - 10.1002/jssc.201200312
DO - 10.1002/jssc.201200312
M3 - Article
C2 - 22815069
SN - 1615-9306
VL - 35
SP - 2538
EP - 2543
JO - Journal of Separation Science
JF - Journal of Separation Science
IS - 19
ER -