Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis

Simon Lambden; Peter Kelly; Blerina Ahmetaj-Shala; Zhen Wang; Benjamin Lee; Manasi Nandi; Belen Torondel; Matthew Delahaye; Laura Dowsett; Sophie Piper; James Tomlinson; Ben Caplin; Lucy Colman; Olga Boruc; Anna Slaviero; Lan Zhao; Eduardo Oliver; Sanjay Khadayate; Mervyn Singer; Francesca Arrigoni; James Leiper

doi:10.1161/ATVBAHA.115.305278

Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis

Simon Lambden
, Peter Kelly
, Blerina Ahmetaj-Shala
, Zhen Wang
, Benjamin Lee
, Manasi Nandi
, Belen Torondel
, Matthew Delahaye
, Laura Dowsett
, Sophie Piper
, James Tomlinson
, Ben Caplin
, Lucy Colman
, Olga Boruc
, Anna Slaviero
, Lan Zhao
, Eduardo Oliver
, Sanjay Khadayate
, Mervyn Singer
, Francesca Arrigoni

James Leiper

Imperial College Healthcare NHS Trust
Imperial College London
King's College London
University College London
Kingston University

Research output: Contribution to journal › Article › peer-review

Abstract

Ddah2 has a regulatory role both in normal physiology and in determining outcome of severe polymicrobial sepsis. Elucidation of this role identifies a mechanism for the observed relationship between Ddah2 polymorphisms, cardiovascular disease, and outcome in sepsis.

Original language	English
Pages (from-to)	1382-1392
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	35
Issue number	6
DOIs	https://doi.org/10.1161/ATVBAHA.115.305278
Publication status	Published - Jun 2015

Access to Document

10.1161/ATVBAHA.115.305278

http://dx.doi.org/10.1161/ATVBAHA.115.305278

Cite this

Lambden, S., Kelly, P., Ahmetaj-Shala, B., Wang, Z., Lee, B., Nandi, M., Torondel, B., Delahaye, M., Dowsett, L., Piper, S., Tomlinson, J., Caplin, B., Colman, L., Boruc, O., Slaviero, A., Zhao, L., Oliver, E., Khadayate, S., Singer, M., ... Leiper, J. (2015). Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis. Arteriosclerosis, Thrombosis, and Vascular Biology, 35(6), 1382-1392. https://doi.org/10.1161/ATVBAHA.115.305278

@article{5aa0db14647d46faa5b20a4993b8b644,

title = "Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis",

abstract = "Ddah2 has a regulatory role both in normal physiology and in determining outcome of severe polymicrobial sepsis. Elucidation of this role identifies a mechanism for the observed relationship between Ddah2 polymorphisms, cardiovascular disease, and outcome in sepsis.",

author = "Simon Lambden and Peter Kelly and Blerina Ahmetaj-Shala and Zhen Wang and Benjamin Lee and Manasi Nandi and Belen Torondel and Matthew Delahaye and Laura Dowsett and Sophie Piper and James Tomlinson and Ben Caplin and Lucy Colman and Olga Boruc and Anna Slaviero and Lan Zhao and Eduardo Oliver and Sanjay Khadayate and Mervyn Singer and Francesca Arrigoni and James Leiper",

year = "2015",

month = jun,

doi = "10.1161/ATVBAHA.115.305278",

language = "English",

volume = "35",

pages = "1382--1392",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

number = "6",

}

Lambden, S, Kelly, P, Ahmetaj-Shala, B, Wang, Z, Lee, B, Nandi, M, Torondel, B, Delahaye, M, Dowsett, L, Piper, S, Tomlinson, J, Caplin, B, Colman, L, Boruc, O, Slaviero, A, Zhao, L, Oliver, E, Khadayate, S, Singer, M, Arrigoni, F & Leiper, J 2015, 'Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 35, no. 6, pp. 1382-1392. https://doi.org/10.1161/ATVBAHA.115.305278

TY - JOUR

T1 - Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis

AU - Lambden, Simon

AU - Kelly, Peter

AU - Ahmetaj-Shala, Blerina

AU - Wang, Zhen

AU - Lee, Benjamin

AU - Nandi, Manasi

AU - Torondel, Belen

AU - Delahaye, Matthew

AU - Dowsett, Laura

AU - Piper, Sophie

AU - Tomlinson, James

AU - Caplin, Ben

AU - Colman, Lucy

AU - Boruc, Olga

AU - Slaviero, Anna

AU - Zhao, Lan

AU - Oliver, Eduardo

AU - Khadayate, Sanjay

AU - Singer, Mervyn

AU - Arrigoni, Francesca

AU - Leiper, James

PY - 2015/6

Y1 - 2015/6

N2 - Ddah2 has a regulatory role both in normal physiology and in determining outcome of severe polymicrobial sepsis. Elucidation of this role identifies a mechanism for the observed relationship between Ddah2 polymorphisms, cardiovascular disease, and outcome in sepsis.

AB - Ddah2 has a regulatory role both in normal physiology and in determining outcome of severe polymicrobial sepsis. Elucidation of this role identifies a mechanism for the observed relationship between Ddah2 polymorphisms, cardiovascular disease, and outcome in sepsis.

UR - http://www.ncbi.nlm.nih.gov/pubmed/25857313

U2 - 10.1161/ATVBAHA.115.305278

DO - 10.1161/ATVBAHA.115.305278

M3 - Article

C2 - 25857313

SN - 1079-5642

VL - 35

SP - 1382

EP - 1392

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 6

ER -

Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis

Abstract

Access to Document

Other files and links

Fingerprint

Cite this