TY - JOUR
T1 - Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in Polymicrobial sepsis
AU - Lambden, Simon
AU - Kelly, Peter
AU - Ahmetaj-Shala, Blerina
AU - Wang, Zhen
AU - Lee, Benjamin
AU - Nandi, Manasi
AU - Torondel, Belen
AU - Delahaye, Matthew
AU - Dowsett, Laura
AU - Piper, Sophie
AU - Tomlinson, James
AU - Caplin, Ben
AU - Colman, Lucy
AU - Boruc, Olga
AU - Slaviero, Anna
AU - Zhao, Lan
AU - Oliver, Eduardo
AU - Khadayate, Sanjay
AU - Singer, Mervyn
AU - Arrigoni, Francesca
AU - Leiper, James
PY - 2015/6
Y1 - 2015/6
N2 - Ddah2 has a regulatory role both in normal physiology and in determining outcome of severe polymicrobial sepsis. Elucidation of this role identifies a mechanism for the observed relationship between Ddah2 polymorphisms, cardiovascular disease, and outcome in sepsis.
AB - Ddah2 has a regulatory role both in normal physiology and in determining outcome of severe polymicrobial sepsis. Elucidation of this role identifies a mechanism for the observed relationship between Ddah2 polymorphisms, cardiovascular disease, and outcome in sepsis.
UR - http://www.ncbi.nlm.nih.gov/pubmed/25857313
U2 - 10.1161/ATVBAHA.115.305278
DO - 10.1161/ATVBAHA.115.305278
M3 - Article
C2 - 25857313
SN - 1079-5642
VL - 35
SP - 1382
EP - 1392
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
IS - 6
ER -