Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: very strong correlation to pleurotin and thioredoxin reductase inhibition

Martin Sweeney; Robert Coyle; Paul Kavanagh; Andrey A. Berezin; Daniele Lo Re; Georgia A. Zissimou; Panayiotis A. Koutentis; Michael P. Carty; Fawaz Aldabbagh

doi:10.1016/j.bmc.2016.05.066

Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: very strong correlation to pleurotin and thioredoxin reductase inhibition

Martin Sweeney
, Robert Coyle
, Paul Kavanagh
, Andrey A. Berezin
, Daniele Lo Re
, Georgia A. Zissimou
, Panayiotis A. Koutentis
, Michael P. Carty
, Fawaz Aldabbagh

Research output: Contribution to journal › Article › peer-review

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Original language	English
Pages (from-to)	3565-3570
Journal	Bioorganic and Medicinal Chemistry
Volume	24
Issue number	16
Early online date	30 May 2016
DOIs	https://doi.org/10.1016/j.bmc.2016.05.066
Publication status	Published - 15 Aug 2016

Bibliographical note

Note: This work was supported by the Irish Research Council, National University of Ireland Galway, the Cyprus Research Promotion Foundation [Grants: NEAYPODOMH/NEKYP/0308/02 and YGEIA/BIOS/0308(BIE)/13] and the University of Cyprus.

Keywords

Biological sciences

Access to Document

10.1016/j.bmc.2016.05.066

Al-Dabbagh-F-39786-AAMAccepted author manuscript, 474 KBLicence: CC BY-NC-ND

https://doi.org/10.1016/j.bmc.2016.05.066

Cite this

Sweeney, M., Coyle, R., Kavanagh, P., Berezin, A. A., Lo Re, D., Zissimou, G. A., Koutentis, P. A., Carty, M. P., & Aldabbagh, F. (2016). Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: very strong correlation to pleurotin and thioredoxin reductase inhibition. Bioorganic and Medicinal Chemistry, 24(16), 3565-3570. https://doi.org/10.1016/j.bmc.2016.05.066

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title = "Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: very strong correlation to pleurotin and thioredoxin reductase inhibition",

keywords = "Biological sciences",

author = "Martin Sweeney and Robert Coyle and Paul Kavanagh and Berezin, \{Andrey A.\} and \{Lo Re\}, Daniele and Zissimou, \{Georgia A.\} and Koutentis, \{Panayiotis A.\} and Carty, \{Michael P.\} and Fawaz Aldabbagh",

note = "Note: This work was supported by the Irish Research Council, National University of Ireland Galway, the Cyprus Research Promotion Foundation [Grants: NEAYPODOMH/NEKYP/0308/02 and YGEIA/BIOS/0308(BIE)/13] and the University of Cyprus.",

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doi = "10.1016/j.bmc.2016.05.066",

language = "English",

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Sweeney, M, Coyle, R, Kavanagh, P, Berezin, AA, Lo Re, D, Zissimou, GA, Koutentis, PA, Carty, MP & Aldabbagh, F 2016, 'Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: very strong correlation to pleurotin and thioredoxin reductase inhibition', Bioorganic and Medicinal Chemistry, vol. 24, no. 16, pp. 3565-3570. https://doi.org/10.1016/j.bmc.2016.05.066

TY - JOUR

T1 - Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones

T2 - very strong correlation to pleurotin and thioredoxin reductase inhibition

AU - Sweeney, Martin

AU - Coyle, Robert

AU - Kavanagh, Paul

AU - Berezin, Andrey A.

AU - Lo Re, Daniele

AU - Zissimou, Georgia A.

AU - Koutentis, Panayiotis A.

AU - Carty, Michael P.

AU - Aldabbagh, Fawaz

N1 - Note: This work was supported by the Irish Research Council, National University of Ireland Galway, the Cyprus Research Promotion Foundation [Grants: NEAYPODOMH/NEKYP/0308/02 and YGEIA/BIOS/0308(BIE)/13] and the University of Cyprus.

PY - 2016/8/15

Y1 - 2016/8/15

KW - Biological sciences

U2 - 10.1016/j.bmc.2016.05.066

DO - 10.1016/j.bmc.2016.05.066

M3 - Article

SN - 0968-0896

VL - 24

SP - 3565

EP - 3570

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 16

ER -