Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs

Matthew Perry; Phillip, J. Stansfeld; Joanne Leaney; Claire Wood; Marcel, J. de Groot; Derek Leishman; Michael, J. Sutcliffe; John, S. Mitcheson

doi:10.1124/mol.105.016741

Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs

Matthew Perry
, Phillip, J. Stansfeld
, Joanne Leaney
, Claire Wood
, Marcel, J. de Groot
, Derek Leishman
, Michael, J. Sutcliffe
, John, S. Mitcheson

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	509-519
Journal	Molecular Pharmacology
Volume	69
Issue number	2
DOIs	https://doi.org/10.1124/mol.105.016741
Publication status	Published - Feb 2006
Externally published	Yes

Keywords

Chemistry

Access to Document

10.1124/mol.105.016741

http://dx.doi.org/10.1124/mol.105.016741

Cite this

@article{ae08589684e3497aa1f79972f56d3f4c,

title = "Drug binding interactions in the inner cavity of hERG channels: Molecular insights from structure-activity relationships of clofilium and ibutilide analogs",

keywords = "Chemistry",

author = "Matthew Perry and Stansfeld, \{Phillip, J.\} and Joanne Leaney and Claire Wood and \{de Groot\}, \{Marcel, J.\} and Derek Leishman and Sutcliffe, \{Michael, J.\} and Mitcheson, \{John, S.\}",

year = "2006",

month = feb,

doi = "10.1124/mol.105.016741",

language = "English",

volume = "69",

pages = "509--519",

journal = "Molecular Pharmacology",

issn = "0026-895X",

publisher = "Elsevier Inc.",

number = "2",

}

TY - JOUR

T1 - Drug binding interactions in the inner cavity of hERG channels

T2 - Molecular insights from structure-activity relationships of clofilium and ibutilide analogs

AU - Perry, Matthew

AU - Stansfeld, Phillip, J.

AU - Leaney, Joanne

AU - Wood, Claire

AU - de Groot, Marcel, J.

AU - Leishman, Derek

AU - Sutcliffe, Michael, J.

AU - Mitcheson, John, S.

PY - 2006/2

Y1 - 2006/2

KW - Chemistry

U2 - 10.1124/mol.105.016741

DO - 10.1124/mol.105.016741

M3 - Article

SN - 0026-895X

VL - 69

SP - 509

EP - 519

JO - Molecular Pharmacology

JF - Molecular Pharmacology

IS - 2

ER -