TY - JOUR
T1 - Dysfunctional mechanotransduction through the YAP/TAZ/Hippo pathway as a feature of chronic disease
AU - Cobbaut, Mathias
AU - Karagil, Simge
AU - Bruno, Lucrezia
AU - Diaz de la Loza, Maria Del Carmen
AU - Mackenzie, Francesca E.
AU - Stolinski, Michael
AU - Elbediwy, Ahmed
N1 - Note: This work was supported by the Francis Crick Institute.
PY - 2020/1/8
Y1 - 2020/1/8
N2 - In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces. These mechanical forces, as experienced by cells and tissues, are then converted into biochemical signals within the cell, leading to a number of cellular mechanisms being activated, including proliferation, differentiation and migration. If the conversion of mechanical cues into biochemical signals is perturbed in any way, then this can be potentially implicated in chronic disease development and processes such as neurological disorders, cancer and obesity. This review will focus on how the interplay between mechanotransduction, cellular structure, metabolism and signalling cascades led by the Hippo-YAP/TAZ axis can lead to a number of chronic diseases and suggest how we can target various pathways in order to design therapeutic targets for these debilitating diseases and conditions.
AB - In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces. These mechanical forces, as experienced by cells and tissues, are then converted into biochemical signals within the cell, leading to a number of cellular mechanisms being activated, including proliferation, differentiation and migration. If the conversion of mechanical cues into biochemical signals is perturbed in any way, then this can be potentially implicated in chronic disease development and processes such as neurological disorders, cancer and obesity. This review will focus on how the interplay between mechanotransduction, cellular structure, metabolism and signalling cascades led by the Hippo-YAP/TAZ axis can lead to a number of chronic diseases and suggest how we can target various pathways in order to design therapeutic targets for these debilitating diseases and conditions.
KW - Biological sciences
UR - https://pubmed.ncbi.nlm.nih.gov/31936297/
U2 - 10.3390/cells9010151
DO - 10.3390/cells9010151
M3 - Article
C2 - 31936297
SN - 2073-4409
VL - 9
JO - Cells
JF - Cells
IS - 1
M1 - 151
ER -