TY - JOUR
T1 - Effects of dietary components on testosterone metabolism via UDP-glucuronosyltransferase (UGT)
AU - Jenkinson, Carl
AU - Petroczi, Andrea
AU - Naughton, Declan P.
PY - 2013/7/8
Y1 - 2013/7/8
N2 - he potential interference in testosterone metabolism through ingested substances has ramifications for: i) a range of pathologies such as prostate cancer, ii) medication contra-indications, iii) disruption to the endocrine system, and iv) potential confounding effects on doping tests. Conjugation of anabolic steroids during phase II metabolism, mainly driven by UDP-glucuronosyltransferase (UGT) 2B7, 2B15 and 2B17, has been shown to be impaired in vitro by a range of compounds including xenobiotics and pharmaceuticals. Following early reports on the effects of a range of xenobiotics on UGT activity in vitro, the work was extended to reveal similar effects with common non-steroidal anti-inflammatory drugs. Notably, recent studies have evidenced inhibitory effects of the common foodstuffs green tea and red wine, along with their constituent flavonoids and catechins. This review amalgamates the existing evidence for the inhibitory effects of various pharmaceutical and dietary substances on the rate of UGT glucuronidation of testosterone; and evaluates the potential consequences for health linked to steroid levels, interaction with treatment drugs metabolised by the UGT enzyme and steroid abuse in sport.
AB - he potential interference in testosterone metabolism through ingested substances has ramifications for: i) a range of pathologies such as prostate cancer, ii) medication contra-indications, iii) disruption to the endocrine system, and iv) potential confounding effects on doping tests. Conjugation of anabolic steroids during phase II metabolism, mainly driven by UDP-glucuronosyltransferase (UGT) 2B7, 2B15 and 2B17, has been shown to be impaired in vitro by a range of compounds including xenobiotics and pharmaceuticals. Following early reports on the effects of a range of xenobiotics on UGT activity in vitro, the work was extended to reveal similar effects with common non-steroidal anti-inflammatory drugs. Notably, recent studies have evidenced inhibitory effects of the common foodstuffs green tea and red wine, along with their constituent flavonoids and catechins. This review amalgamates the existing evidence for the inhibitory effects of various pharmaceutical and dietary substances on the rate of UGT glucuronidation of testosterone; and evaluates the potential consequences for health linked to steroid levels, interaction with treatment drugs metabolised by the UGT enzyme and steroid abuse in sport.
KW - Allied health professions and studies
UR - http://www.frontiersin.org/Experimental_Endocrinology/10.3389/fendo.2013.00080/abstract
UR - http://www.ncbi.nlm.nih.gov/pubmed/23847592
U2 - 10.3389/fendo.2013.00080
DO - 10.3389/fendo.2013.00080
M3 - Article
C2 - 23847592
SN - 1664-2392
VL - 4
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology
IS - 80
ER -