Factors associated with retinal vessel traits in the Canadian longitudinal study on aging

Mohan Rakesh; Marie-H├®l├¿ne Roy-Gagnon; David Maberley; Ellen E. Freeman; Alexis O'Neil; Roshan A. Welikala; Sarah Barman; Christopher G. Owen; Alicja R. Rudnicka

doi:10.1167/iovs.66.3.13

Factors associated with retinal vessel traits in the Canadian longitudinal study on aging

Mohan Rakesh
, Marie-H├®l├¿ne Roy-Gagnon
, David Maberley
, Ellen E. Freeman
, Alexis O'Neil
, Roshan A. Welikala
, Sarah Barman
, Christopher G. Owen
, Alicja R. Rudnicka

Research output: Contribution to journal › Article › peer-review

Abstract

This study aims to determine the factors cross-sectionally and longitudinally associated with retinal vessel diameter, total area, and tortuosity in the Canadian Longitudinal Study on Aging (CLSA). Current smoking was strongly associated with wider arteriolar and venular diameters and their widening over 3 years (P < 0.05). Current smoking was also associated with a larger arteriolar and venular area and a 3-year increase in venular area (P < 0.05). Obesity was positively associated with venular diameter, total venular area, 3-year change in total venular area, and venular tortuosity (P < 0.05). Diastolic blood pressure was negatively associated with both arteriolar and venular diameter, area, and tortuosity, both cross-sectionally and longitudinally (P < 0.05). Diabetes was associated with wider arteriolar diameters cross-sectionally, and type 1 diabetes was associated with 3-year widening of arteriolar diameters (P < 0.05).

Original language	English
Article number	13
Journal	Investigative Ophthalmology and Visual Science
Volume	66
Issue number	3
DOIs	https://doi.org/10.1167/iovs.66.3.13
Publication status	Published - 6 Mar 2025

Bibliographical note

Note: This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the CLSA is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference LSA 94473 and the Canada Foundation for Innovation.

Keywords

Pre-clinical and human biological sciences

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10.1167/iovs.66.3.13

Barman-S-56894-VoRFinal published version, 656 KBLicence: CC BY-NC-ND

https://doi.org/10.1167/iovs.66.3.13

Cite this

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title = "Factors associated with retinal vessel traits in the Canadian longitudinal study on aging",

abstract = "This study aims to determine the factors cross-sectionally and longitudinally associated with retinal vessel diameter, total area, and tortuosity in the Canadian Longitudinal Study on Aging (CLSA). Current smoking was strongly associated with wider arteriolar and venular diameters and their widening over 3 years (P < 0.05). Current smoking was also associated with a larger arteriolar and venular area and a 3-year increase in venular area (P < 0.05). Obesity was positively associated with venular diameter, total venular area, 3-year change in total venular area, and venular tortuosity (P < 0.05). Diastolic blood pressure was negatively associated with both arteriolar and venular diameter, area, and tortuosity, both cross-sectionally and longitudinally (P < 0.05). Diabetes was associated with wider arteriolar diameters cross-sectionally, and type 1 diabetes was associated with 3-year widening of arteriolar diameters (P < 0.05).",

keywords = "Pre-clinical and human biological sciences",

author = "Mohan Rakesh and Marie-H├{\textregistered}l├¿ne Roy-Gagnon and David Maberley and Freeman, \{Ellen E.\} and Alexis O'Neil and Welikala, \{Roshan A.\} and Sarah Barman and Owen, \{Christopher G.\} and Rudnicka, \{Alicja R.\}",

note = "Note: This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the CLSA is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference LSA 94473 and the Canada Foundation for Innovation.",

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doi = "10.1167/iovs.66.3.13",

language = "English",

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T1 - Factors associated with retinal vessel traits in the Canadian longitudinal study on aging

AU - Rakesh, Mohan

AU - Roy-Gagnon, Marie-H├®l├¿ne

AU - Maberley, David

AU - Freeman, Ellen E.

AU - O'Neil, Alexis

AU - Welikala, Roshan A.

AU - Barman, Sarah

AU - Owen, Christopher G.

AU - Rudnicka, Alicja R.

N1 - Note: This research was made possible using the data/biospecimens collected by the Canadian Longitudinal Study on Aging (CLSA). Funding for the CLSA is provided by the Government of Canada through the Canadian Institutes of Health Research (CIHR) under grant reference LSA 94473 and the Canada Foundation for Innovation.

PY - 2025/3/6

Y1 - 2025/3/6

N2 - This study aims to determine the factors cross-sectionally and longitudinally associated with retinal vessel diameter, total area, and tortuosity in the Canadian Longitudinal Study on Aging (CLSA). Current smoking was strongly associated with wider arteriolar and venular diameters and their widening over 3 years (P < 0.05). Current smoking was also associated with a larger arteriolar and venular area and a 3-year increase in venular area (P < 0.05). Obesity was positively associated with venular diameter, total venular area, 3-year change in total venular area, and venular tortuosity (P < 0.05). Diastolic blood pressure was negatively associated with both arteriolar and venular diameter, area, and tortuosity, both cross-sectionally and longitudinally (P < 0.05). Diabetes was associated with wider arteriolar diameters cross-sectionally, and type 1 diabetes was associated with 3-year widening of arteriolar diameters (P < 0.05).

AB - This study aims to determine the factors cross-sectionally and longitudinally associated with retinal vessel diameter, total area, and tortuosity in the Canadian Longitudinal Study on Aging (CLSA). Current smoking was strongly associated with wider arteriolar and venular diameters and their widening over 3 years (P < 0.05). Current smoking was also associated with a larger arteriolar and venular area and a 3-year increase in venular area (P < 0.05). Obesity was positively associated with venular diameter, total venular area, 3-year change in total venular area, and venular tortuosity (P < 0.05). Diastolic blood pressure was negatively associated with both arteriolar and venular diameter, area, and tortuosity, both cross-sectionally and longitudinally (P < 0.05). Diabetes was associated with wider arteriolar diameters cross-sectionally, and type 1 diabetes was associated with 3-year widening of arteriolar diameters (P < 0.05).

KW - Pre-clinical and human biological sciences

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DO - 10.1167/iovs.66.3.13

M3 - Article

SN - 0146-0404

VL - 66

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

IS - 3

M1 - 13

ER -

Factors associated with retinal vessel traits in the Canadian longitudinal study on aging

Abstract

Bibliographical note

Keywords

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