Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Xikun Han; Jue Sheng Ong; Alex W. Hewitt; Ayellet V. Segrè; John M. Rouhana; Andrew R. Hamel; Robert P. Igo Jr; Adriana Iglesias; Owen M. Siggs; Terri L. Young; Veronique Vitart; Mark Simcoe; Nishani Amersinghe; Angela J. Cree; Rene Hohn; Alicia Poplawski; Li Jia Chen; Shi-Song Rong; Sarah A. Barman; GIGA study group; 23 and Me Research Team; Gen Tamiya; Yukihiro Shiga; Masayuki Yamamoto; Toru Nakazawa; Hannah Currant; Ewan Birney; Xin Wang; Adam Auton; Michelle K. Lupton; Nicholas G. Martin; Adeyinka Ashaye; Olusola Olawoye; Susan E. Williams; Stephen Akafo; Michele Ramsay; Kazuki Hashimoto; Yoichiro Kamatani; Masato Akiyama; Yukihide Momozawa; Paul J. Foster; Peng T. Khaw; James E. Morgan; Nicholas G. Strouthidis; Peter Kraft; Jae H. Kang; Chi Pui Pang; Francesca Pasutto; Paul Mitchell; Andrew J. Lotery; Aarno Palotie; Cornelia van Duijn; Jonathan L. Haines; Chris Hammond; Louis R. Pasquale; Caroline C. W. Klaver; Michael Hauser; Chiea Chuen Khor; David A. Mackey; Michiaki Kubo; Ching-Yu Cheng; Jamie E. Craig; Stuart MacGregor; Janey L. Wiggs; Alberta A. H. J. Thiadens; Juha Karjalainen; Steffen Uebe; Ronald B. Melles; K. Saidas Nair; Robert Luben; ANZRAG consortium; Biobank Japan project; FinnGen study; UK Biobank Eye and Vision Consortium; Navya S. Josyula; Jessica N. Cooke Bailey; Pieter W. M. Bonnemaijer; Tin Aung; Eranga Nishanthie Vithana; NEIGHBORHOOD consortium; Helene Choquet; Ayub Qassim; Puya Gharahkhani; Eric Jorgenson; Pirro Hysi; Anthony P. Khawaja; Sarah Pendergrass

doi:10.1038/s41467-020-20851-4

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Xikun Han
, Jue Sheng Ong
, Alex W. Hewitt
, Ayellet V. Segrè
, John M. Rouhana
, Andrew R. Hamel
, Robert P. Igo Jr
, Adriana Iglesias
, Owen M. Siggs
, Terri L. Young
, Veronique Vitart
, Mark Simcoe
, Nishani Amersinghe
, Angela J. Cree
, Rene Hohn
, Alicia Poplawski
, Li Jia Chen
, Shi-Song Rong
, Sarah A. Barman
, GIGA study group

23 and Me Research Team, Gen Tamiya, Yukihiro Shiga, Masayuki Yamamoto, Toru Nakazawa, Hannah Currant, Ewan Birney, Xin Wang, Adam Auton, Michelle K. Lupton, Nicholas G. Martin, Adeyinka Ashaye, Olusola Olawoye, Susan E. Williams, Stephen Akafo, Michele Ramsay, Kazuki Hashimoto, Yoichiro Kamatani, Masato Akiyama, Yukihide Momozawa, Paul J. Foster, Peng T. Khaw, James E. Morgan, Nicholas G. Strouthidis, Peter Kraft, Jae H. Kang, Chi Pui Pang, Francesca Pasutto, Paul Mitchell, Andrew J. Lotery, Aarno Palotie, Cornelia van Duijn, Jonathan L. Haines, Chris Hammond, Louis R. Pasquale, Caroline C. W. Klaver, Michael Hauser, Chiea Chuen Khor, David A. Mackey, Michiaki Kubo, Ching-Yu Cheng, Jamie E. Craig, Stuart MacGregor, Janey L. Wiggs, Alberta A. H. J. Thiadens, Juha Karjalainen, Steffen Uebe, Ronald B. Melles, K. Saidas Nair, Robert Luben, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, Navya S. Josyula, Jessica N. Cooke Bailey, Pieter W. M. Bonnemaijer, Tin Aung, Eranga Nishanthie Vithana, NEIGHBORHOOD consortium, Helene Choquet, Ayub Qassim, Puya Gharahkhani, Eric Jorgenson, Pirro Hysi, Anthony P. Khawaja, Sarah Pendergrass

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Original language	English
Article number	1258
Journal	Nature Communications
Volume	12
Early online date	24 Feb 2021
DOIs	https://doi.org/10.1038/s41467-020-20851-4
Publication status	Published - 24 Feb 2021

Bibliographical note

Note: This work supported by National Health and Medical Research Council (NHMRC) of Australia [grant numbers #1107098; 1116360, 1116495, 1023911], the Ophthalmic Research Institute of Australia, the BrightFocus Foundation, UK and Eire Glaucoma Society, Royal Liverpool University Hospital, International Glaucoma Association-Royal College of Ophthalmologists, National Health and Medical Research Council Investigator Grant (#1173390), National Health and Medical Research Council Fellowships, Moorfields Eye Charity Career Development Fellowship, a UK Research and Innovation Future Leaders Fellowship, Alcon Research Institute Young Investigator Award, the Medical Research Council [grant numbers: MR/N003284/1, MC-UU_12015/1, and MC_PC_13048], Cancer Research UK [grant number C864/A14136], NIH grants P30 EY014104, R01 EY015473, and R01 EY022305, Business Finland [grant numbers: HUS 4685/31/2016 and UH 4386/31/2016], AbbVie Inc, AstraZeneca UK Ltd, Biogen MA Inc, Celgene Corporation, Celgene International II Sàrl, Genentech Inc, Merck Sharp & Dohme Corp, Pfizer Inc., GlaxoSmithKline, Sanofi, Maze Therapeutics Inc., Janssen Biotech Inc, the National Eye Institute/National Institutes of Health [R01EY018246], the National Institutes of Health Center for Inherited Disease Research, University of Wisconsin Centennial Scholars Award, Research to Prevent Blindness, Inc.

Keywords

Biological sciences

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Barman-S-48739-VoRFinal published version, 2.52 MBLicence: CC BY

https://doi.org/10.1038/s41467-020-20851-4

Cite this

Han, X., Ong, J. S., Hewitt, A. W., Segrè, A. V., Rouhana, J. M., Hamel, A. R., Igo Jr, R. P., Iglesias, A., Siggs, O. M., Young, T. L., Vitart, V., Simcoe, M., Amersinghe, N., Cree, A. J., Hohn, R., Poplawski, A., Chen, L. J., Rong, S.-S., Barman, S. A., ... Pendergrass, S. (2021). Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nature Communications, 12, Article 1258. https://doi.org/10.1038/s41467-020-20851-4

@article{7a6c6c32851649bb909abf74e19d24a9,

title = "Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries",

keywords = "Biological sciences",

author = "Xikun Han and Ong, \{Jue Sheng\} and Hewitt, \{Alex W.\} and Segr{\`e}, \{Ayellet V.\} and Rouhana, \{John M.\} and Hamel, \{Andrew R.\} and \{Igo Jr\}, \{Robert P.\} and Adriana Iglesias and Siggs, \{Owen M.\} and Young, \{Terri L.\} and Veronique Vitart and Mark Simcoe and Nishani Amersinghe and Cree, \{Angela J.\} and Rene Hohn and Alicia Poplawski and Chen, \{Li Jia\} and Shi-Song Rong and Barman, \{Sarah A.\} and \{GIGA study group\} and \{23 and Me Research Team\} and Gen Tamiya and Yukihiro Shiga and Masayuki Yamamoto and Toru Nakazawa and Hannah Currant and Ewan Birney and Xin Wang and Adam Auton and Lupton, \{Michelle K.\} and Martin, \{Nicholas G.\} and Adeyinka Ashaye and Olusola Olawoye and Williams, \{Susan E.\} and Stephen Akafo and Michele Ramsay and Kazuki Hashimoto and Yoichiro Kamatani and Masato Akiyama and Yukihide Momozawa and Foster, \{Paul J.\} and Khaw, \{Peng T.\} and Morgan, \{James E.\} and Strouthidis, \{Nicholas G.\} and Peter Kraft and Kang, \{Jae H.\} and Pang, \{Chi Pui\} and Francesca Pasutto and Paul Mitchell and Lotery, \{Andrew J.\} and Aarno Palotie and \{van Duijn\}, Cornelia and Haines, \{Jonathan L.\} and Chris Hammond and Pasquale, \{Louis R.\} and Klaver, \{Caroline C. W.\} and Michael Hauser and Khor, \{Chiea Chuen\} and Mackey, \{David A.\} and Michiaki Kubo and Ching-Yu Cheng and Craig, \{Jamie E.\} and Stuart MacGregor and Wiggs, \{Janey L.\} and Thiadens, \{Alberta A. H. J.\} and Juha Karjalainen and Steffen Uebe and Melles, \{Ronald B.\} and Nair, \{K. Saidas\} and Robert Luben and \{ANZRAG consortium\} and \{Biobank Japan project\} and \{FinnGen study\} and \{UK Biobank Eye and Vision Consortium\} and Josyula, \{Navya S.\} and \{Cooke Bailey\}, \{Jessica N.\} and Bonnemaijer, \{Pieter W. M.\} and Tin Aung and Vithana, \{Eranga Nishanthie\} and \{NEIGHBORHOOD consortium\} and Helene Choquet and Ayub Qassim and Puya Gharahkhani and Eric Jorgenson and Pirro Hysi and Khawaja, \{Anthony P.\} and Sarah Pendergrass",

note = "Note: This work supported by National Health and Medical Research Council (NHMRC) of Australia [grant numbers \#1107098; 1116360, 1116495, 1023911], the Ophthalmic Research Institute of Australia, the BrightFocus Foundation, UK and Eire Glaucoma Society, Royal Liverpool University Hospital, International Glaucoma Association-Royal College of Ophthalmologists, National Health and Medical Research Council Investigator Grant (\#1173390), National Health and Medical Research Council Fellowships, Moorfields Eye Charity Career Development Fellowship, a UK Research and Innovation Future Leaders Fellowship, Alcon Research Institute Young Investigator Award, the Medical Research Council [grant numbers: MR/N003284/1, MC-UU\_12015/1, and MC\_PC\_13048], Cancer Research UK [grant number C864/A14136], NIH grants P30 EY014104, R01 EY015473, and R01 EY022305, Business Finland [grant numbers: HUS 4685/31/2016 and UH 4386/31/2016], AbbVie Inc, AstraZeneca UK Ltd, Biogen MA Inc, Celgene Corporation, Celgene International II S{\`a}rl, Genentech Inc, Merck Sharp \& Dohme Corp, Pfizer Inc., GlaxoSmithKline, Sanofi, Maze Therapeutics Inc., Janssen Biotech Inc, the National Eye Institute/National Institutes of Health [R01EY018246], the National Institutes of Health Center for Inherited Disease Research, University of Wisconsin Centennial Scholars Award, Research to Prevent Blindness, Inc.",

year = "2021",

month = feb,

day = "24",

doi = "10.1038/s41467-020-20851-4",

language = "English",

volume = "12",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

}

Han, X, Ong, JS, Hewitt, AW, Segrè, AV, Rouhana, JM, Hamel, AR, Igo Jr, RP, Iglesias, A, Siggs, OM, Young, TL, Vitart, V, Simcoe, M, Amersinghe, N, Cree, AJ, Hohn, R, Poplawski, A, Chen, LJ, Rong, S-S, Barman, SA, GIGA study group, 23 and Me Research Team, Tamiya, G, Shiga, Y, Yamamoto, M, Nakazawa, T, Currant, H, Birney, E, Wang, X, Auton, A, Lupton, MK, Martin, NG, Ashaye, A, Olawoye, O, Williams, SE, Akafo, S, Ramsay, M, Hashimoto, K, Kamatani, Y, Akiyama, M, Momozawa, Y, Foster, PJ, Khaw, PT, Morgan, JE, Strouthidis, NG, Kraft, P, Kang, JH, Pang, CP, Pasutto, F, Mitchell, P, Lotery, AJ, Palotie, A, van Duijn, C, Haines, JL, Hammond, C, Pasquale, LR, Klaver, CCW, Hauser, M, Khor, CC, Mackey, DA, Kubo, M, Cheng, C-Y, Craig, JE, MacGregor, S, Wiggs, JL, Thiadens, AAHJ, Karjalainen, J, Uebe, S, Melles, RB, Nair, KS, Luben, R, ANZRAG consortium, Biobank Japan project, FinnGen study, UK Biobank Eye and Vision Consortium, Josyula, NS, Cooke Bailey, JN, Bonnemaijer, PWM, Aung, T, Vithana, EN, NEIGHBORHOOD consortium, Choquet, H, Qassim, A, Gharahkhani, P, Jorgenson, E, Hysi, P, Khawaja, AP & Pendergrass, S 2021, 'Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries', Nature Communications, vol. 12, 1258. https://doi.org/10.1038/s41467-020-20851-4

TY - JOUR

T1 - Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

AU - Han, Xikun

AU - Ong, Jue Sheng

AU - Hewitt, Alex W.

AU - Segrè, Ayellet V.

AU - Rouhana, John M.

AU - Hamel, Andrew R.

AU - Igo Jr, Robert P.

AU - Iglesias, Adriana

AU - Siggs, Owen M.

AU - Young, Terri L.

AU - Vitart, Veronique

AU - Simcoe, Mark

AU - Amersinghe, Nishani

AU - Cree, Angela J.

AU - Hohn, Rene

AU - Poplawski, Alicia

AU - Chen, Li Jia

AU - Rong, Shi-Song

AU - Barman, Sarah A.

AU - GIGA study group, null

AU - 23 and Me Research Team, null

AU - Tamiya, Gen

AU - Shiga, Yukihiro

AU - Yamamoto, Masayuki

AU - Nakazawa, Toru

AU - Currant, Hannah

AU - Birney, Ewan

AU - Wang, Xin

AU - Auton, Adam

AU - Lupton, Michelle K.

AU - Martin, Nicholas G.

AU - Ashaye, Adeyinka

AU - Olawoye, Olusola

AU - Williams, Susan E.

AU - Akafo, Stephen

AU - Ramsay, Michele

AU - Hashimoto, Kazuki

AU - Kamatani, Yoichiro

AU - Akiyama, Masato

AU - Momozawa, Yukihide

AU - Foster, Paul J.

AU - Khaw, Peng T.

AU - Morgan, James E.

AU - Strouthidis, Nicholas G.

AU - Kraft, Peter

AU - Kang, Jae H.

AU - Pang, Chi Pui

AU - Pasutto, Francesca

AU - Mitchell, Paul

AU - Lotery, Andrew J.

AU - Palotie, Aarno

AU - van Duijn, Cornelia

AU - Haines, Jonathan L.

AU - Hammond, Chris

AU - Pasquale, Louis R.

AU - Klaver, Caroline C. W.

AU - Hauser, Michael

AU - Khor, Chiea Chuen

AU - Mackey, David A.

AU - Kubo, Michiaki

AU - Cheng, Ching-Yu

AU - Craig, Jamie E.

AU - MacGregor, Stuart

AU - Wiggs, Janey L.

AU - Thiadens, Alberta A. H. J.

AU - Karjalainen, Juha

AU - Uebe, Steffen

AU - Melles, Ronald B.

AU - Nair, K. Saidas

AU - Luben, Robert

AU - ANZRAG consortium, null

AU - Biobank Japan project, null

AU - FinnGen study, null

AU - UK Biobank Eye and Vision Consortium, null

AU - Josyula, Navya S.

AU - Cooke Bailey, Jessica N.

AU - Bonnemaijer, Pieter W. M.

AU - Aung, Tin

AU - Vithana, Eranga Nishanthie

AU - NEIGHBORHOOD consortium, null

AU - Choquet, Helene

AU - Qassim, Ayub

AU - Gharahkhani, Puya

AU - Jorgenson, Eric

AU - Hysi, Pirro

AU - Khawaja, Anthony P.

AU - Pendergrass, Sarah

N1 - Note: This work supported by National Health and Medical Research Council (NHMRC) of Australia [grant numbers #1107098; 1116360, 1116495, 1023911], the Ophthalmic Research Institute of Australia, the BrightFocus Foundation, UK and Eire Glaucoma Society, Royal Liverpool University Hospital, International Glaucoma Association-Royal College of Ophthalmologists, National Health and Medical Research Council Investigator Grant (#1173390), National Health and Medical Research Council Fellowships, Moorfields Eye Charity Career Development Fellowship, a UK Research and Innovation Future Leaders Fellowship, Alcon Research Institute Young Investigator Award, the Medical Research Council [grant numbers: MR/N003284/1, MC-UU_12015/1, and MC_PC_13048], Cancer Research UK [grant number C864/A14136], NIH grants P30 EY014104, R01 EY015473, and R01 EY022305, Business Finland [grant numbers: HUS 4685/31/2016 and UH 4386/31/2016], AbbVie Inc, AstraZeneca UK Ltd, Biogen MA Inc, Celgene Corporation, Celgene International II Sàrl, Genentech Inc, Merck Sharp & Dohme Corp, Pfizer Inc., GlaxoSmithKline, Sanofi, Maze Therapeutics Inc., Janssen Biotech Inc, the National Eye Institute/National Institutes of Health [R01EY018246], the National Institutes of Health Center for Inherited Disease Research, University of Wisconsin Centennial Scholars Award, Research to Prevent Blindness, Inc.

PY - 2021/2/24

Y1 - 2021/2/24

KW - Biological sciences

U2 - 10.1038/s41467-020-20851-4

DO - 10.1038/s41467-020-20851-4

M3 - Article

SN - 2041-1723

VL - 12

JO - Nature Communications

JF - Nature Communications

M1 - 1258

ER -