GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Ville Karhunen; Ulla Sovio; Doug Speed; Lachlan J. M. Coin; Marie Loh; Sheila J. Barton; Lawrence J. Beilin; Claudia Flexeder; Stephen Franks; Timothy M. Frayling; Rachel M. Freathy; Paul Elliott; Asa K. Hedman; Esa Laara; Holger Prokisch; Harald Grallert; Timo A. Lakka; Karl-Heinz Herzig; George Davey Smith; Paul O'Reilly; Janine F. Felix; Jessica L. Buxton; Alexandra I. F. Blakemore; Ken K. Ong; Vincent W. V. Jaddoe; Struan F. A. Grant; Sylvain Sebert; Mark I. McCarthy; Marjo-Riitta Jarvelin; Elisabeth Widen; Hakon Hakonarson; Andrew T. Hattersley; Debbie A. Lawlor; Mads Melbye; Tarunveer S. Ahluwalia; Shikta Das; H. Rob Taal; Nicole M. Warrington; Alexandra M. Lewin; Marika Kaakinen; Hans Bisgaard; Klaus Bonnelykke; Diana L. Cousminer; Elisabeth Thiering; Nicholas J. Timpson; Tom A. Bond; Estelle Lowry; Rohia Alili; Ida J. Hatoum; Katharina Schramm; Rufus Cartwright; Alina Rodriguez; Marco Banterle; Marcella Marinelli; Iona Y. Millwood; Lyle J. Palmer; Craig E. Pennell; John R. Perry; Susan M. Ring; Markku J. Savolainen; Fernando Rivadeneira; Marie Standl; Jordi Sunyer; Carla M. T. Tiesler; Andre G. Uitterlinden; William Schierding; Justin M. O'Sullivan; Inga Prokopenko; Marie-Aline Charles; Vincenzo Salerno; Karine Clement; Annique A. J. Claringbould; Cornelia M. van Duijn; Elena Moltchanova; Johan G. Eriksson; Cathy Elks; Bjarke Feenstra; Joachim Heinrich; Barbara Heude; John W. Holloway; Albert Hofman; Jonathan P. Bradfield; Frank Geller; Elina Hypponen; Hazel Inskip; Lee M. Kaplan; Christopher D. Brown; Xavier Estivill; Virpi Lindi; Alexessander Couto Alves; N. Maneka G. De Silva

doi:10.1126/sciadv.aaw3095

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Ville Karhunen, Ulla Sovio, Doug Speed, Lachlan J. M. Coin, Marie Loh, Sheila J. Barton, Lawrence J. Beilin, Claudia Flexeder, Stephen Franks, Timothy M. Frayling, Rachel M. Freathy, Paul Elliott, Asa K. Hedman, Esa Laara, Holger Prokisch, Harald Grallert, Timo A. Lakka, Karl-Heinz Herzig, George Davey Smith, Paul O'ReillyJanine F. Felix, Jessica L. Buxton, Alexandra I. F. Blakemore, Ken K. Ong, Vincent W. V. Jaddoe, Struan F. A. Grant, Sylvain Sebert, Mark I. McCarthy, Marjo-Riitta Jarvelin, Elisabeth Widen, Hakon Hakonarson, Andrew T. Hattersley, Debbie A. Lawlor, Mads Melbye, Tarunveer S. Ahluwalia, Shikta Das, H. Rob Taal, Nicole M. Warrington, Alexandra M. Lewin, Marika Kaakinen, Hans Bisgaard, Klaus Bonnelykke, Diana L. Cousminer, Elisabeth Thiering, Nicholas J. Timpson, Tom A. Bond, Estelle Lowry, Rohia Alili, Ida J. Hatoum, Katharina Schramm, Rufus Cartwright, Alina Rodriguez, Marco Banterle, Marcella Marinelli, Iona Y. Millwood, Lyle J. Palmer, Craig E. Pennell, John R. Perry, Susan M. Ring, Markku J. Savolainen, Fernando Rivadeneira, Marie Standl, Jordi Sunyer, Carla M. T. Tiesler, Andre G. Uitterlinden, William Schierding, Justin M. O'Sullivan, Inga Prokopenko, Marie-Aline Charles, Vincenzo Salerno, Karine Clement, Annique A. J. Claringbould, Cornelia M. van Duijn, Elena Moltchanova, Johan G. Eriksson, Cathy Elks, Bjarke Feenstra, Joachim Heinrich, Barbara Heude, John W. Holloway, Albert Hofman, Jonathan P. Bradfield, Frank Geller, Elina Hypponen, Hazel Inskip, Lee M. Kaplan, Christopher D. Brown, Xavier Estivill, Virpi Lindi, Alexessander Couto Alves, N. Maneka G. De Silva

Research output: Contribution to journal › Article › peer-review

Abstract

Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

Original language	English
Article number	eaaw3095
Journal	Science Advances
Volume	5
Issue number	9
Early online date	4 Sept 2019
DOIs	https://doi.org/10.1126/sciadv.aaw3095
Publication status	Published - 4 Sept 2019

Bibliographical note

Note: This work was supported by: UK Medical
Research Council and Wellcome Trust (grant reference 102215/2/13/2); NIH grant R01
HD056465; Danish National Research Foundation; NIH Genes, Environment and Health
Initiative (GEI; U01HG004423); NIH GEI (U01HG004438); Lundbeck Foundation (R19-A2059);
Danish Medical Research Council (09-065592); French Ministry of Research; INSERM; South
West NHS Research and Development; Exeter NHS Research and Development; Netherlands
Organization for Health Research and Development (VIDI 016. 136. 361); European Union's
Horizon 2020 research and innovation programme under grant agreement nos. 633595
(DynaHEALTH), 733206 (LIFECYCLE), and 721567 (CAPICE); European Research Council (ERC
consolidator grant, ERC-2014-CoG-648916); Academy of Finland (project grants 209072 and
129255); British Heart Foundation and Academy of Finland (grants 134839 and 129287);
National Public Health Institute, Helsinki, Finland; World Cancer Research Fund (WCRF UK) and
World Cancer Research Fund International (2017/1641); Wellcome Trust (WT205915);
European Commission under the Marie Curie Intra-European Fellowship (project MARVEL,
PIEF-GA-2013-626461); Instituto de Salud Carlos III (CB06/02/0041, FIS PI041436, PI081151,
PI041705, and PS09/00432 and FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079,
05/1052, 06/1213, 07/0314, and 09/02647); Spanish Ministry of Science and Innovation
(SAF2008-00357); European Commission (ENGAGE project and grant agreement
HEALTH-F4-2007-201413); Fundació La Marató de TV3; Generalitat de Catalunya-CIRIT
1999SGR 00241; Federal Ministry for Environment (IUF Düsseldorf, FKZ 20462296); National
Health and Medical Research Council of Australia (grant IDs 403981 and 003209); Canadian
Institutes of Health Research (grant ID MOP-82893); Royal Society of New Zealand Marsden
Fund (grant 16-UOO-072); Academy of Finland (project grants 104781, 120315, 129269,
1114194, Center of Excellence in Complex Disease Genetics, and SALVE); University Hospital
Oulu; Biocenter; University of Oulu, Finland (75617); European Commission (EURO-BLCS,
Framework 5 award QLG1-CT-2000-01643); NHLBI grant 5R01HL087679-02 through the
STAMPEED program (1RL1MH083268-01); NIH/NIMH (5R01MH63706:02); Medical Research
Council, United Kingdom (G0500539 and G0600705, PrevMetSyn/SALVE, MR/M013138,
G0802782); Wellcome Trust (project grant GR069224); and EU Framework Programme 7
EurHEALTHAgeing 277849.

Keywords

Biological sciences

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Karhunen, V., Sovio, U., Speed, D., Coin, L. J. M., Loh, M., Barton, S. J., Beilin, L. J., Flexeder, C., Franks, S., Frayling, T. M., Freathy, R. M., Elliott, P., Hedman, A. K., Laara, E., Prokisch, H., Grallert, H., Lakka, T. A., Herzig, K.-H., Smith, G. D., ... De Silva, N. M. G. (2019). GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI. Science Advances, 5(9), Article eaaw3095. https://doi.org/10.1126/sciadv.aaw3095

@article{10f475b9fade46eb92f7a14f5c6e3ebd,

title = "GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI",

abstract = "Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.",

keywords = "Biological sciences",

author = "Ville Karhunen and Ulla Sovio and Doug Speed and Coin, \{Lachlan J. M.\} and Marie Loh and Barton, \{Sheila J.\} and Beilin, \{Lawrence J.\} and Claudia Flexeder and Stephen Franks and Frayling, \{Timothy M.\} and Freathy, \{Rachel M.\} and Paul Elliott and Hedman, \{Asa K.\} and Esa Laara and Holger Prokisch and Harald Grallert and Lakka, \{Timo A.\} and Karl-Heinz Herzig and Smith, \{George Davey\} and Paul O'Reilly and Felix, \{Janine F.\} and Buxton, \{Jessica L.\} and Blakemore, \{Alexandra I. F.\} and Ong, \{Ken K.\} and Jaddoe, \{Vincent W. V.\} and Grant, \{Struan F. A.\} and Sylvain Sebert and McCarthy, \{Mark I.\} and Marjo-Riitta Jarvelin and Elisabeth Widen and Hakon Hakonarson and Hattersley, \{Andrew T.\} and Lawlor, \{Debbie A.\} and Mads Melbye and Ahluwalia, \{Tarunveer S.\} and Shikta Das and Taal, \{H. Rob\} and Warrington, \{Nicole M.\} and Lewin, \{Alexandra M.\} and Marika Kaakinen and Hans Bisgaard and Klaus Bonnelykke and Cousminer, \{Diana L.\} and Elisabeth Thiering and Timpson, \{Nicholas J.\} and Bond, \{Tom A.\} and Estelle Lowry and Rohia Alili and Hatoum, \{Ida J.\} and Katharina Schramm and Rufus Cartwright and Alina Rodriguez and Marco Banterle and Marcella Marinelli and Millwood, \{Iona Y.\} and Palmer, \{Lyle J.\} and Pennell, \{Craig E.\} and Perry, \{John R.\} and Ring, \{Susan M.\} and Savolainen, \{Markku J.\} and Fernando Rivadeneira and Marie Standl and Jordi Sunyer and Tiesler, \{Carla M. T.\} and Uitterlinden, \{Andre G.\} and William Schierding and O'Sullivan, \{Justin M.\} and Inga Prokopenko and Marie-Aline Charles and Vincenzo Salerno and Karine Clement and Claringbould, \{Annique A. J.\} and \{van Duijn\}, \{Cornelia M.\} and Elena Moltchanova and Eriksson, \{Johan G.\} and Cathy Elks and Bjarke Feenstra and Joachim Heinrich and Barbara Heude and Holloway, \{John W.\} and Albert Hofman and Bradfield, \{Jonathan P.\} and Frank Geller and Elina Hypponen and Hazel Inskip and Kaplan, \{Lee M.\} and Brown, \{Christopher D.\} and Xavier Estivill and Virpi Lindi and \{Couto Alves\}, Alexessander and \{De Silva\}, \{N. Maneka G.\}",

note = "Note: This work was supported by: UK Medical Research Council and Wellcome Trust (grant reference 102215/2/13/2); NIH grant R01 HD056465; Danish National Research Foundation; NIH Genes, Environment and Health Initiative (GEI; U01HG004423); NIH GEI (U01HG004438); Lundbeck Foundation (R19-A2059); Danish Medical Research Council (09-065592); French Ministry of Research; INSERM; South West NHS Research and Development; Exeter NHS Research and Development; Netherlands Organization for Health Research and Development (VIDI 016. 136. 361); European Union's Horizon 2020 research and innovation programme under grant agreement nos. 633595 (DynaHEALTH), 733206 (LIFECYCLE), and 721567 (CAPICE); European Research Council (ERC consolidator grant, ERC-2014-CoG-648916); Academy of Finland (project grants 209072 and 129255); British Heart Foundation and Academy of Finland (grants 134839 and 129287); National Public Health Institute, Helsinki, Finland; World Cancer Research Fund (WCRF UK) and World Cancer Research Fund International (2017/1641); Wellcome Trust (WT205915); European Commission under the Marie Curie Intra-European Fellowship (project MARVEL, PIEF-GA-2013-626461); Instituto de Salud Carlos III (CB06/02/0041, FIS PI041436, PI081151, PI041705, and PS09/00432 and FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, and 09/02647); Spanish Ministry of Science and Innovation (SAF2008-00357); European Commission (ENGAGE project and grant agreement HEALTH-F4-2007-201413); Fundaci{\'o} La Marat{\'o} de TV3; Generalitat de Catalunya-CIRIT 1999SGR 00241; Federal Ministry for Environment (IUF D{\"u}sseldorf, FKZ 20462296); National Health and Medical Research Council of Australia (grant IDs 403981 and 003209); Canadian Institutes of Health Research (grant ID MOP-82893); Royal Society of New Zealand Marsden Fund (grant 16-UOO-072); Academy of Finland (project grants 104781, 120315, 129269, 1114194, Center of Excellence in Complex Disease Genetics, and SALVE); University Hospital Oulu; Biocenter; University of Oulu, Finland (75617); European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643); NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01); NIH/NIMH (5R01MH63706:02); Medical Research Council, United Kingdom (G0500539 and G0600705, PrevMetSyn/SALVE, MR/M013138, G0802782); Wellcome Trust (project grant GR069224); and EU Framework Programme 7 EurHEALTHAgeing 277849.",

year = "2019",

month = sep,

day = "4",

doi = "10.1126/sciadv.aaw3095",

language = "English",

volume = "5",

journal = "Science Advances",

issn = "2375-2548",

publisher = "American Association for the Advancement of Science",

number = "9",

}

Karhunen, V, Sovio, U, Speed, D, Coin, LJM, Loh, M, Barton, SJ, Beilin, LJ, Flexeder, C, Franks, S, Frayling, TM, Freathy, RM, Elliott, P, Hedman, AK, Laara, E, Prokisch, H, Grallert, H, Lakka, TA, Herzig, K-H, Smith, GD, O'Reilly, P, Felix, JF, Buxton, JL, Blakemore, AIF, Ong, KK, Jaddoe, VWV, Grant, SFA, Sebert, S, McCarthy, MI, Jarvelin, M-R, Widen, E, Hakonarson, H, Hattersley, AT, Lawlor, DA, Melbye, M, Ahluwalia, TS, Das, S, Taal, HR, Warrington, NM, Lewin, AM, Kaakinen, M, Bisgaard, H, Bonnelykke, K, Cousminer, DL, Thiering, E, Timpson, NJ, Bond, TA, Lowry, E, Alili, R, Hatoum, IJ, Schramm, K, Cartwright, R, Rodriguez, A, Banterle, M, Marinelli, M, Millwood, IY, Palmer, LJ, Pennell, CE, Perry, JR, Ring, SM, Savolainen, MJ, Rivadeneira, F, Standl, M, Sunyer, J, Tiesler, CMT, Uitterlinden, AG, Schierding, W, O'Sullivan, JM, Prokopenko, I, Charles, M-A, Salerno, V, Clement, K, Claringbould, AAJ, van Duijn, CM, Moltchanova, E, Eriksson, JG, Elks, C, Feenstra, B, Heinrich, J, Heude, B, Holloway, JW, Hofman, A, Bradfield, JP, Geller, F, Hypponen, E, Inskip, H, Kaplan, LM, Brown, CD, Estivill, X, Lindi, V, Couto Alves, A & De Silva, NMG 2019, 'GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI', Science Advances, vol. 5, no. 9, eaaw3095. https://doi.org/10.1126/sciadv.aaw3095

TY - JOUR

T1 - GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

AU - Karhunen, Ville

AU - Sovio, Ulla

AU - Speed, Doug

AU - Coin, Lachlan J. M.

AU - Loh, Marie

AU - Barton, Sheila J.

AU - Beilin, Lawrence J.

AU - Flexeder, Claudia

AU - Franks, Stephen

AU - Frayling, Timothy M.

AU - Freathy, Rachel M.

AU - Elliott, Paul

AU - Hedman, Asa K.

AU - Laara, Esa

AU - Prokisch, Holger

AU - Grallert, Harald

AU - Lakka, Timo A.

AU - Herzig, Karl-Heinz

AU - Smith, George Davey

AU - O'Reilly, Paul

AU - Felix, Janine F.

AU - Buxton, Jessica L.

AU - Blakemore, Alexandra I. F.

AU - Ong, Ken K.

AU - Jaddoe, Vincent W. V.

AU - Grant, Struan F. A.

AU - Sebert, Sylvain

AU - McCarthy, Mark I.

AU - Jarvelin, Marjo-Riitta

AU - Widen, Elisabeth

AU - Hakonarson, Hakon

AU - Hattersley, Andrew T.

AU - Lawlor, Debbie A.

AU - Melbye, Mads

AU - Ahluwalia, Tarunveer S.

AU - Das, Shikta

AU - Taal, H. Rob

AU - Warrington, Nicole M.

AU - Lewin, Alexandra M.

AU - Kaakinen, Marika

AU - Bisgaard, Hans

AU - Bonnelykke, Klaus

AU - Cousminer, Diana L.

AU - Thiering, Elisabeth

AU - Timpson, Nicholas J.

AU - Bond, Tom A.

AU - Lowry, Estelle

AU - Alili, Rohia

AU - Hatoum, Ida J.

AU - Schramm, Katharina

AU - Cartwright, Rufus

AU - Rodriguez, Alina

AU - Banterle, Marco

AU - Marinelli, Marcella

AU - Millwood, Iona Y.

AU - Palmer, Lyle J.

AU - Pennell, Craig E.

AU - Perry, John R.

AU - Ring, Susan M.

AU - Savolainen, Markku J.

AU - Rivadeneira, Fernando

AU - Standl, Marie

AU - Sunyer, Jordi

AU - Tiesler, Carla M. T.

AU - Uitterlinden, Andre G.

AU - Schierding, William

AU - O'Sullivan, Justin M.

AU - Prokopenko, Inga

AU - Charles, Marie-Aline

AU - Salerno, Vincenzo

AU - Clement, Karine

AU - Claringbould, Annique A. J.

AU - van Duijn, Cornelia M.

AU - Moltchanova, Elena

AU - Eriksson, Johan G.

AU - Elks, Cathy

AU - Feenstra, Bjarke

AU - Heinrich, Joachim

AU - Heude, Barbara

AU - Holloway, John W.

AU - Hofman, Albert

AU - Bradfield, Jonathan P.

AU - Geller, Frank

AU - Hypponen, Elina

AU - Inskip, Hazel

AU - Kaplan, Lee M.

AU - Brown, Christopher D.

AU - Estivill, Xavier

AU - Lindi, Virpi

AU - Couto Alves, Alexessander

AU - De Silva, N. Maneka G.

N1 - Note: This work was supported by: UK Medical Research Council and Wellcome Trust (grant reference 102215/2/13/2); NIH grant R01 HD056465; Danish National Research Foundation; NIH Genes, Environment and Health Initiative (GEI; U01HG004423); NIH GEI (U01HG004438); Lundbeck Foundation (R19-A2059); Danish Medical Research Council (09-065592); French Ministry of Research; INSERM; South West NHS Research and Development; Exeter NHS Research and Development; Netherlands Organization for Health Research and Development (VIDI 016. 136. 361); European Union's Horizon 2020 research and innovation programme under grant agreement nos. 633595 (DynaHEALTH), 733206 (LIFECYCLE), and 721567 (CAPICE); European Research Council (ERC consolidator grant, ERC-2014-CoG-648916); Academy of Finland (project grants 209072 and 129255); British Heart Foundation and Academy of Finland (grants 134839 and 129287); National Public Health Institute, Helsinki, Finland; World Cancer Research Fund (WCRF UK) and World Cancer Research Fund International (2017/1641); Wellcome Trust (WT205915); European Commission under the Marie Curie Intra-European Fellowship (project MARVEL, PIEF-GA-2013-626461); Instituto de Salud Carlos III (CB06/02/0041, FIS PI041436, PI081151, PI041705, and PS09/00432 and FIS-FEDER 03/1615, 04/1509, 04/1112, 04/1931, 05/1079, 05/1052, 06/1213, 07/0314, and 09/02647); Spanish Ministry of Science and Innovation (SAF2008-00357); European Commission (ENGAGE project and grant agreement HEALTH-F4-2007-201413); Fundació La Marató de TV3; Generalitat de Catalunya-CIRIT 1999SGR 00241; Federal Ministry for Environment (IUF Düsseldorf, FKZ 20462296); National Health and Medical Research Council of Australia (grant IDs 403981 and 003209); Canadian Institutes of Health Research (grant ID MOP-82893); Royal Society of New Zealand Marsden Fund (grant 16-UOO-072); Academy of Finland (project grants 104781, 120315, 129269, 1114194, Center of Excellence in Complex Disease Genetics, and SALVE); University Hospital Oulu; Biocenter; University of Oulu, Finland (75617); European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643); NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01); NIH/NIMH (5R01MH63706:02); Medical Research Council, United Kingdom (G0500539 and G0600705, PrevMetSyn/SALVE, MR/M013138, G0802782); Wellcome Trust (project grant GR069224); and EU Framework Programme 7 EurHEALTHAgeing 277849.

PY - 2019/9/4

Y1 - 2019/9/4

N2 - Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

AB - Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap with those of adult health. We found a robust overlap between the genetics of child and adult body mass index (BMI), with variants associated with adult BMI acting as early as 4 to 6 years old. However, we demonstrated a completely distinct genetic makeup for peak BMI during infancy, influenced by variation at the LEPR/LEPROT locus. These findings suggest that different genetic factors control infant and child BMI. In light of the obesity epidemic, these findings are important to inform the timing and targets of prevention strategies.

KW - Biological sciences

U2 - 10.1126/sciadv.aaw3095

DO - 10.1126/sciadv.aaw3095

M3 - Article

SN - 2375-2548

VL - 5

JO - Science Advances

JF - Science Advances

IS - 9

M1 - eaaw3095

ER -

GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI

Abstract

Bibliographical note

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