TY - JOUR
T1 - Healthcare resource consumption and related costs of patients estimated with treatment-resistant depression in Italy
AU - Perrone, Valentina
AU - Sangiorgi, Diego
AU - Andretta, Margherita
AU - Ducci, Giuseppe
AU - Forti, Bruno
AU - Francesa Morel, Pier Cesare
AU - Gambera, Marco
AU - Maina, Giuseppe
AU - Mencacci, Claudio
AU - Mennini, Francesco Saverio
AU - Zanalda, Enrico
AU - Degli Esposti, Luca
N1 - Note: This work was supported by Janssen Italy.
PY - 2021
Y1 - 2021
N2 - Purpose: To analyse the healthcare resource consumption and related costs for the Italian National Health System of patients estimated to be affected by treatment-resistant depression (TRD) in Italy. Patients and methods: This was an observational retrospective study based on administrative databases, including those related to residential/semiresidential structures, of Veneto Region and the Local Health Unit of Bergamo in Italy (for a total of around 6 million health-assisted subjects). Between July 2011 and December 2017, all adult patients with a third antidepressant (AD) after ÔëÑ2 AD (each one with at least ÔëÑ4 weeks duration, ÔëÑ1 prescription at maximum dosage reported in datasheets, a grace period Ôëñ30 days when switching AD and treatment maintained ÔëÑ9 months) were included. Overall and psychiatry-related healthcare resources consumption and related costs were estimated on a 12-months based analysis. Data were re-proportioned to the Italian population. Results: We have previously estimated a total of 101,455 patients with TRD in Italy (130,049 considering the mean maximum dosage of AD). Of them, 44.2% had at least a psychiatric hospitalization/visit or accessed a residential/semiresidential structure, and 31% added another AD or a mood stabilizer/antipsychotic drug. Patients with at least one psychiatry-related hospitalization increased over the number of antidepressant lines from 12.0% during first line up to 24.5% during fourth line. Direct healthcare costs increased from €4,405 for first line to €9,251 from fifth line onwards. Psychiatry-related costs went from €1,817 (first line) to €4,606 (fifth line onwards) and were mainly driven by residential/semiresidential structures and hospitalizations. Conclusion: An upward trend with number of AD lines was observed for all healthcare resource utilization and consequently for all direct costs, thus indicating an increasing burden for patients as they move forward AD lines.
AB - Purpose: To analyse the healthcare resource consumption and related costs for the Italian National Health System of patients estimated to be affected by treatment-resistant depression (TRD) in Italy. Patients and methods: This was an observational retrospective study based on administrative databases, including those related to residential/semiresidential structures, of Veneto Region and the Local Health Unit of Bergamo in Italy (for a total of around 6 million health-assisted subjects). Between July 2011 and December 2017, all adult patients with a third antidepressant (AD) after ÔëÑ2 AD (each one with at least ÔëÑ4 weeks duration, ÔëÑ1 prescription at maximum dosage reported in datasheets, a grace period Ôëñ30 days when switching AD and treatment maintained ÔëÑ9 months) were included. Overall and psychiatry-related healthcare resources consumption and related costs were estimated on a 12-months based analysis. Data were re-proportioned to the Italian population. Results: We have previously estimated a total of 101,455 patients with TRD in Italy (130,049 considering the mean maximum dosage of AD). Of them, 44.2% had at least a psychiatric hospitalization/visit or accessed a residential/semiresidential structure, and 31% added another AD or a mood stabilizer/antipsychotic drug. Patients with at least one psychiatry-related hospitalization increased over the number of antidepressant lines from 12.0% during first line up to 24.5% during fourth line. Direct healthcare costs increased from €4,405 for first line to €9,251 from fifth line onwards. Psychiatry-related costs went from €1,817 (first line) to €4,606 (fifth line onwards) and were mainly driven by residential/semiresidential structures and hospitalizations. Conclusion: An upward trend with number of AD lines was observed for all healthcare resource utilization and consequently for all direct costs, thus indicating an increasing burden for patients as they move forward AD lines.
KW - Allied health professions and studies
KW - Depression
KW - Healthcare Costs
KW - Real-world
KW - Trd
U2 - 10.2147/ceor.s314111
DO - 10.2147/ceor.s314111
M3 - Article
SN - 1178-6981
VL - 13
SP - 629
EP - 635
JO - ClinicoEconomics and Outcomes Research
JF - ClinicoEconomics and Outcomes Research
ER -