HLA-DRB1*15 and pediatric aplastic anemia

Fatma S. Oguz; Nevin Yalman; Ali Sarper Diler; Rusdu Oguz; Sema Anak; Mehmet Tevfik Dorak

HLA-DRB1*15 and pediatric aplastic anemia

Fatma S. Oguz
, Nevin Yalman
, Ali Sarper Diler
, Rusdu Oguz
, Sema Anak
, Mehmet Tevfik Dorak

Istanbul University

Research output: Contribution to journal › Article › peer-review

Abstract

We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in SAA which confers responsiveness to treatment.

Original language	English
Pages (from-to)	772-774
Journal	Haematologica
Volume	87
Issue number	7
Publication status	Published - 2002

Keywords

Biological sciences

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http://www.haematologica.org/content/87/7/772

Cite this

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title = "HLA-DRB1*15 and pediatric aplastic anemia",

abstract = "We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in SAA which confers responsiveness to treatment.",

keywords = "Biological sciences",

author = "Oguz, \{Fatma S.\} and Nevin Yalman and Diler, \{Ali Sarper\} and Rusdu Oguz and Sema Anak and Dorak, \{Mehmet Tevfik\}",

year = "2002",

language = "English",

volume = "87",

pages = "772--774",

journal = "Haematologica",

issn = "0390-6078",

publisher = "Ferrata Storti Foundation",

number = "7",

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TY - JOUR

T1 - HLA-DRB1*15 and pediatric aplastic anemia

AU - Oguz, Fatma S.

AU - Yalman, Nevin

AU - Diler, Ali Sarper

AU - Oguz, Rusdu

AU - Anak, Sema

AU - Dorak, Mehmet Tevfik

PY - 2002

Y1 - 2002

N2 - We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in SAA which confers responsiveness to treatment.

AB - We report a positive association between HLA-DRB1*15 (p= 0.0002) in Turkish patients with pediatric severe aplastic anemia (SAA) and a paradoxically favorable influence of the susceptibility marker on the clinical response to immunosuppressive therapy. These findings point to an immune mechanism mediated by DRB1*15 in SAA which confers responsiveness to treatment.

KW - Biological sciences

UR - https://www.ncbi.nlm.nih.gov/pubmed/12091130

M3 - Article

C2 - 12091130

SN - 0390-6078

VL - 87

SP - 772

EP - 774

JO - Haematologica

JF - Haematologica

IS - 7

ER -

HLA-DRB1*15 and pediatric aplastic anemia

Abstract

Keywords

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