Abstract
The effect of aurothiomalate on the status of a wide range of low-molecular-mass endogenous metabolites in blood plasma obtained from animals treated with an intravenous dose of this second-line agent (150 mg/kg) has been assessed by high field proton Hahn spin-echo NMR spectroscopy. As well as modulating the effective concentrations of NMR-detectable biomolecules, aurothiomalate induces a time-dependent decrease in plasma levels of triacylglycerols with a corresponding elevation in the concentration of the ketone body 3-D-hydroxybutyrate, indicating an increased utilisation of fats for energy in rats treated with this 1:1 gold(I)-thiolate complex. These observations may reflect the toxic side-effects that are associated with aurothiomalate treatment.
| Original language | English |
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| Publication status | Published - 1991 |
| Externally published | Yes |
| Event | Satellite Symposium of the 9th International Congress of Pharmacology: Drugs in Inflammation - Noordwijk, Netherlands Duration: 28 Jun 1990 → 29 Jun 1990 |
Conference
| Conference | Satellite Symposium of the 9th International Congress of Pharmacology: Drugs in Inflammation |
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| Period | 28/06/90 → 29/06/90 |
Keywords
- Allied health professions and studies