Insights into schizophrenia using positron emission tomography: building the evidence and refining the focus

Nora S. Vyas; Neva H. Patel; Kuldip S. Nijran; Adil Al-Nahhas; Basant K. Puri

doi:10.1192/bjp.bp.109.073882

Insights into schizophrenia using positron emission tomography: building the evidence and refining the focus

Nora S. Vyas
, Neva H. Patel
, Kuldip S. Nijran
, Adil Al-Nahhas
, Basant K. Puri

King's College London
Imperial College Healthcare NHS Trust

Research output: Contribution to journal › Article › peer-review

Abstract

Schizophrenia involves dysregulation in dopaminergic transmission. Studies show heightened presynaptic striatal dopaminergic function and elevated striatal D(2)/D(3) receptor density in the brain. Cognitive impairments result from hypostimulation of D(1) receptors and are associated with dysfunction in the prefrontal cortex. Here we discuss relevant positron emissions tomography (PET) studies and provide future directions.

Original language	English
Pages (from-to)	3-4
Journal	British Journal of Psychiatry
Volume	197
Issue number	1
DOIs	https://doi.org/10.1192/bjp.bp.109.073882
Publication status	Published - Jul 2010

Keywords

Psychiatry, neuroscience and clinical psychology

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10.1192/bjp.bp.109.073882

http://dx.doi.org/10.1192/bjp.bp.109.073882

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abstract = "Schizophrenia involves dysregulation in dopaminergic transmission. Studies show heightened presynaptic striatal dopaminergic function and elevated striatal D(2)/D(3) receptor density in the brain. Cognitive impairments result from hypostimulation of D(1) receptors and are associated with dysfunction in the prefrontal cortex. Here we discuss relevant positron emissions tomography (PET) studies and provide future directions.",

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AU - Puri, Basant K.

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AB - Schizophrenia involves dysregulation in dopaminergic transmission. Studies show heightened presynaptic striatal dopaminergic function and elevated striatal D(2)/D(3) receptor density in the brain. Cognitive impairments result from hypostimulation of D(1) receptors and are associated with dysfunction in the prefrontal cortex. Here we discuss relevant positron emissions tomography (PET) studies and provide future directions.

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Insights into schizophrenia using positron emission tomography: building the evidence and refining the focus

Abstract

Keywords

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