Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

Christopher, R. Pudney; Sam Hay; Jiayun Pang; Claire Costello; David Leys; Michael, J. Sutcliffe; Nigel, S. Scrutton

doi:10.1021/ja074463h

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

Christopher, R. Pudney, Sam Hay, Jiayun Pang, Claire Costello, David Leys, Michael, J. Sutcliffe, Nigel, S. Scrutton

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	13949-13956
Journal	Journal of the American Chemical Society
Volume	129
Issue number	45
DOIs	https://doi.org/10.1021/ja074463h
Publication status	Published - Nov 2007
Externally published	Yes

Keywords

Chemistry

Access to Document

10.1021/ja074463h

http://dx.doi.org/10.1021/ja074463h

Cite this

@article{18682b66a52f4f58a16f9e7ea7b61ceb,

title = "Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms",

keywords = "Chemistry",

author = "Pudney, \{Christopher, R.\} and Sam Hay and Jiayun Pang and Claire Costello and David Leys and Sutcliffe, \{Michael, J.\} and Scrutton, \{Nigel, S.\}",

year = "2007",

month = nov,

doi = "10.1021/ja074463h",

language = "English",

volume = "129",

pages = "13949--13956",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "45",

}

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms. / Pudney, Christopher, R.; Hay, Sam; Pang, Jiayun et al.
In: Journal of the American Chemical Society, Vol. 129, No. 45, 11.2007, p. 13949-13956.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

AU - Pudney, Christopher, R.

AU - Hay, Sam

AU - Pang, Jiayun

AU - Costello, Claire

AU - Leys, David

AU - Sutcliffe, Michael, J.

AU - Scrutton, Nigel, S.

PY - 2007/11

Y1 - 2007/11

KW - Chemistry

U2 - 10.1021/ja074463h

DO - 10.1021/ja074463h

M3 - Article

SN - 0002-7863

VL - 129

SP - 13949

EP - 13956

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 45

ER -