Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

Christopher, R. Pudney; Sam Hay; Jiayun Pang; Claire Costello; David Leys; Michael, J. Sutcliffe; Nigel, S. Scrutton

doi:10.1021/ja074463h

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

Christopher, R. Pudney
, Sam Hay
, Jiayun Pang
, Claire Costello
, David Leys
, Michael, J. Sutcliffe
, Nigel, S. Scrutton

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	13949-13956
Journal	Journal of the American Chemical Society
Volume	129
Issue number	45
DOIs	https://doi.org/10.1021/ja074463h
Publication status	Published - Nov 2007
Externally published	Yes

Keywords

Chemistry

Access to Document

10.1021/ja074463h

http://dx.doi.org/10.1021/ja074463h

Cite this

@article{18682b66a52f4f58a16f9e7ea7b61ceb,

title = "Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms",

keywords = "Chemistry",

author = "Pudney, \{Christopher, R.\} and Sam Hay and Jiayun Pang and Claire Costello and David Leys and Sutcliffe, \{Michael, J.\} and Scrutton, \{Nigel, S.\}",

year = "2007",

month = nov,

doi = "10.1021/ja074463h",

language = "English",

volume = "129",

pages = "13949--13956",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

publisher = "American Chemical Society",

number = "45",

}

Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms. / Pudney, Christopher, R.; Hay, Sam; Pang, Jiayun et al.
In: Journal of the American Chemical Society, Vol. 129, No. 45, 11.2007, p. 13949-13956.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms

AU - Pudney, Christopher, R.

AU - Hay, Sam

AU - Pang, Jiayun

AU - Costello, Claire

AU - Leys, David

AU - Sutcliffe, Michael, J.

AU - Scrutton, Nigel, S.

PY - 2007/11

Y1 - 2007/11

KW - Chemistry

U2 - 10.1021/ja074463h

DO - 10.1021/ja074463h

M3 - Article

SN - 0002-7863

VL - 129

SP - 13949

EP - 13956

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 45

ER -