Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner

A. Waheed; M.H.R. Ludtmann; N. Pakes; S. Robery; A. Kuspa; C. Dinh; D. Baines; R.S.B. Williams; M. Carew

doi:10.1111/bph.12443

Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner

A. Waheed
, M.H.R. Ludtmann
, N. Pakes
, S. Robery
, A. Kuspa
, C. Dinh
, D. Baines
, R.S.B. Williams
, M. Carew

Research output: Contribution to journal › Article › peer-review

Abstract

The action of naringenin on cell growth in the phylogenetically diverse systems of Dictyostelium and mammalian kidney cells, suggests a conserved effect mediated by polycystin-2 (TRPP2). Further studies will investigate naringenin as a potential new therapeutic agent in ADPKD.

Original language	English
Pages (from-to)	2659-2670
Journal	British Journal of Pharmacology
Volume	171
Issue number	10
Early online date	28 Apr 2014
DOIs	https://doi.org/10.1111/bph.12443
Publication status	Published - 31 May 2014

Keywords

polycystic kidney disease
polycystin-2
naringenin
dictyostelium
polyphenol
cell growth
Pharmacy

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10.1111/bph.12443

http://dx.doi.org/10.1111/bph.12443

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title = "Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner",

abstract = "The action of naringenin on cell growth in the phylogenetically diverse systems of Dictyostelium and mammalian kidney cells, suggests a conserved effect mediated by polycystin-2 (TRPP2). Further studies will investigate naringenin as a potential new therapeutic agent in ADPKD.",

keywords = "polycystic kidney disease, polycystin-2, naringenin, dictyostelium, polyphenol, cell growth, Pharmacy",

author = "A. Waheed and M.H.R. Ludtmann and N. Pakes and S. Robery and A. Kuspa and C. Dinh and D. Baines and R.S.B. Williams and M. Carew",

year = "2014",

month = may,

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TY - JOUR

T1 - Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner

AU - Waheed, A.

AU - Ludtmann, M.H.R.

AU - Pakes, N.

AU - Robery, S.

AU - Kuspa, A.

AU - Dinh, C.

AU - Baines, D.

AU - Williams, R.S.B.

AU - Carew, M.

PY - 2014/5/31

Y1 - 2014/5/31

N2 - The action of naringenin on cell growth in the phylogenetically diverse systems of Dictyostelium and mammalian kidney cells, suggests a conserved effect mediated by polycystin-2 (TRPP2). Further studies will investigate naringenin as a potential new therapeutic agent in ADPKD.

AB - The action of naringenin on cell growth in the phylogenetically diverse systems of Dictyostelium and mammalian kidney cells, suggests a conserved effect mediated by polycystin-2 (TRPP2). Further studies will investigate naringenin as a potential new therapeutic agent in ADPKD.

KW - polycystic kidney disease

KW - polycystin-2

KW - naringenin

KW - dictyostelium

KW - polyphenol

KW - cell growth

KW - Pharmacy

U2 - 10.1111/bph.12443

DO - 10.1111/bph.12443

M3 - Article

C2 - 24116661

SN - 0007-1188

VL - 171

SP - 2659

EP - 2670

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

IS - 10

ER -

Naringenin inhibits the growth of Dictyostelium and MDCK-derived cysts in a polycystin-2 (TRPP2)-dependent manner

Abstract

Keywords

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