New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Thiemo Pfab; Sheila J Barton; Beverley M Shields; Marjan Kerkhof; Elisabeth M van Leeuwen; Anthony J Fulford; Zolt├ín Kutalik; Jing Hua Zhao; Marcel den Hoed; Anubha Mahajan; Virpi Lindi; Liang-Kee Goh; Jouke-Jan Hottenga; Ying Wu; Olli T Raitakari; Marie N Harder; Aline Meirhaeghe; Ioanna Ntalla; Rany M Salem; Karen A Jameson; Kaixin Zhou; Dorota M Monies; Vasiliki Lagou; Mirna Kirin; Jani Heikkinen; Linda S Adair; Fowzan S Alkuraya; Ali Al-Odaib; Philippe Amouyel; Ehm Astrid Andersson; Amanda J Bennett; Alexandra I F Blakemore; Jessica L Buxton; Jean Dallongeville; Shikta Das; Eco J C de Geus; Xavier Estivill; Claudia Flexeder; Philippe Froguel; Frank Geller; Keith M Godfrey; Fr├®d├®ric Gottrand; Christopher J Groves; Torben Hansen; Joel N Hirschhorn; Albert Hofman; Mads V Hollegaard; David M Hougaard; Elina Hypp├Ânen; Hazel M Inskip; Aaron Isaacs; Torben J├©rgensen; Christina Kanaka-Gantenbein; John P Kemp; Wieland Kiess; Tuomas O Kilpel├ñinen; Norman Klopp; Bridget A Knight; Christopher W Kuzawa; George McMahon; John P Newnham; Harri Niinikoski; Ben A Oostra; Louise Pedersen; Dirkje S Postma; Susan M Ring; Fernando Rivadeneira; Neil R Robertson; Sylvain Sebert; Olli Simell; Torsten Slowinski; Carla M T Tiesler; Anke T├Ânjes; Allan Vaag; Jorma S Viikari; Jacqueline M Vink; Nadja Hawwa Vissing; Nicholas J Wareham; Gonneke Willemsen; Daniel R Witte; Haitao Zhang; Jianhua Zhao; James F Wilson; Michael Stumvoll; Andrew M Prentice; Brian F Meyer; Ewan R Pearson; Colin A G Boreham; Cyrus Cooper; Matthew W Gillman; George V Dedoussis; Luis A Moreno; Oluf Pedersen; Maiju Saarinen; Karen L Mohlke; Dorret I Boomsma; Seang-Mei Saw; Timo A Lakka; Antje K├Ârner; Ruth J F Loos; Ken K Ong; Peter Vollenweider; Cornelia M van Duijn; Gerard H Koppelman; Andrew T Hattersley; John W Holloway; Berthold Hocher; Joachim Heinrich; Chris Power; Mads Melbye; M├▓nica Guxens; Craig E Pennell; Klaus B├©nnelykke; Hans Bisgaard; Johan G Eriksson; Elisabeth Wid├®n; Hakon Hakonarson; Andr├® G Uitterlinden; Anneli Pouta; Debbie A Lawlor; George Davey Smith; Timothy M Frayling; Mark I McCarthy; Struan F A Grant; Vincent W V Jaddoe; Marjo-Riitta Jarvelin; Nicholas J Timpson; Inga Prokopenko; Rachel M Freathy; Momoko Horikoshi; Branwen J Hennig; Jonathan P Bradfield; Beate St Pourcain; David M Evans; Pimphen Charoen; Marika Kaakinen; Diana L Cousminer; Terho Lehtim├ñki; Eskil Kreiner-M├©ller; Nicole M Warrington; Mariona Bustamante; Bjarke Feenstra; Diane J Berry; Elisabeth Thiering; Hanieh Yaghootkar; Dennis O Mook-Kanamori; Ulla Sovio; H Rob Taal

doi:10.1038/ng.2477

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

Thiemo Pfab, Sheila J Barton, Beverley M Shields, Marjan Kerkhof, Elisabeth M van Leeuwen, Anthony J Fulford, Zolt├ín Kutalik, Jing Hua Zhao, Marcel den Hoed, Anubha Mahajan, Virpi Lindi, Liang-Kee Goh, Jouke-Jan Hottenga, Ying Wu, Olli T Raitakari, Marie N Harder, Aline Meirhaeghe, Ioanna Ntalla, Rany M Salem, Karen A JamesonKaixin Zhou, Dorota M Monies, Vasiliki Lagou, Mirna Kirin, Jani Heikkinen, Linda S Adair, Fowzan S Alkuraya, Ali Al-Odaib, Philippe Amouyel, Ehm Astrid Andersson, Amanda J Bennett, Alexandra I F Blakemore, Jessica L Buxton, Jean Dallongeville, Shikta Das, Eco J C de Geus, Xavier Estivill, Claudia Flexeder, Philippe Froguel, Frank Geller, Keith M Godfrey, Fr├®d├®ric Gottrand, Christopher J Groves, Torben Hansen, Joel N Hirschhorn, Albert Hofman, Mads V Hollegaard, David M Hougaard, Elina Hypp├Ânen, Hazel M Inskip, Aaron Isaacs, Torben J├©rgensen, Christina Kanaka-Gantenbein, John P Kemp, Wieland Kiess, Tuomas O Kilpel├ñinen, Norman Klopp, Bridget A Knight, Christopher W Kuzawa, George McMahon, John P Newnham, Harri Niinikoski, Ben A Oostra, Louise Pedersen, Dirkje S Postma, Susan M Ring, Fernando Rivadeneira, Neil R Robertson, Sylvain Sebert, Olli Simell, Torsten Slowinski, Carla M T Tiesler, Anke T├Ânjes, Allan Vaag, Jorma S Viikari, Jacqueline M Vink, Nadja Hawwa Vissing, Nicholas J Wareham, Gonneke Willemsen, Daniel R Witte, Haitao Zhang, Jianhua Zhao, James F Wilson, Michael Stumvoll, Andrew M Prentice, Brian F Meyer, Ewan R Pearson, Colin A G Boreham, Cyrus Cooper, Matthew W Gillman, George V Dedoussis, Luis A Moreno, Oluf Pedersen, Maiju Saarinen, Karen L Mohlke, Dorret I Boomsma, Seang-Mei Saw, Timo A Lakka, Antje K├Ârner, Ruth J F Loos, Ken K Ong, Peter Vollenweider, Cornelia M van Duijn, Gerard H Koppelman, Andrew T Hattersley, John W Holloway, Berthold Hocher, Joachim Heinrich, Chris Power, Mads Melbye, M├▓nica Guxens, Craig E Pennell, Klaus B├©nnelykke, Hans Bisgaard, Johan G Eriksson, Elisabeth Wid├®n, Hakon Hakonarson, Andr├® G Uitterlinden, Anneli Pouta, Debbie A Lawlor, George Davey Smith, Timothy M Frayling, Mark I McCarthy, Struan F A Grant, Vincent W V Jaddoe, Marjo-Riitta Jarvelin, Nicholas J Timpson, Inga Prokopenko, Rachel M Freathy, Momoko Horikoshi, Branwen J Hennig, Jonathan P Bradfield, Beate St Pourcain, David M Evans, Pimphen Charoen, Marika Kaakinen, Diana L Cousminer, Terho Lehtim├ñki, Eskil Kreiner-M├©ller, Nicole M Warrington, Mariona Bustamante, Bjarke Feenstra, Diane J Berry, Elisabeth Thiering, Hanieh Yaghootkar, Dennis O Mook-Kanamori, Ulla Sovio, H Rob Taal

Research output: Contribution to journal › Article › peer-review

Abstract

Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

Original language	English
Pages (from-to)	76-82
Journal	Nature Genetics
Volume	45
Issue number	1
Early online date	2 Dec 2012
DOIs	https://doi.org/10.1038/ng.2477
Publication status	Published - 31 Jan 2013

Keywords

Biological sciences

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10.1038/ng.2477

https://doi.org/10.1038/ng.2477

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Pfab, T., Barton, S. J., Shields, B. M., Kerkhof, M., van Leeuwen, E. M., Fulford, A. J., Kutalik, Z., Zhao, J. H., den Hoed, M., Mahajan, A., Lindi, V., Goh, L.-K., Hottenga, J.-J., Wu, Y., Raitakari, O. T., Harder, M. N., Meirhaeghe, A., Ntalla, I., Salem, R. M., ... Taal, H. R. (2013). New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nature Genetics, 45(1), 76-82. https://doi.org/10.1038/ng.2477

@article{a47f8eb028134707a874a24be03dd784,

title = "New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism",

abstract = "Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.",

keywords = "Biological sciences",

author = "Thiemo Pfab and Barton, \{Sheila J\} and Shields, \{Beverley M\} and Marjan Kerkhof and \{van Leeuwen\}, \{Elisabeth M\} and Fulford, \{Anthony J\} and Zolt├{\'i}n Kutalik and Zhao, \{Jing Hua\} and \{den Hoed\}, Marcel and Anubha Mahajan and Virpi Lindi and Liang-Kee Goh and Jouke-Jan Hottenga and Ying Wu and Raitakari, \{Olli T\} and Harder, \{Marie N\} and Aline Meirhaeghe and Ioanna Ntalla and Salem, \{Rany M\} and Jameson, \{Karen A\} and Kaixin Zhou and Monies, \{Dorota M\} and Vasiliki Lagou and Mirna Kirin and Jani Heikkinen and Adair, \{Linda S\} and Alkuraya, \{Fowzan S\} and Ali Al-Odaib and Philippe Amouyel and Andersson, \{Ehm Astrid\} and Bennett, \{Amanda J\} and Blakemore, \{Alexandra I F\} and Buxton, \{Jessica L\} and Jean Dallongeville and Shikta Das and \{de Geus\}, \{Eco J C\} and Xavier Estivill and Claudia Flexeder and Philippe Froguel and Frank Geller and Godfrey, \{Keith M\} and Fr├{\textregistered}d├{\textregistered}ric Gottrand and Groves, \{Christopher J\} and Torben Hansen and Hirschhorn, \{Joel N\} and Albert Hofman and Hollegaard, \{Mads V\} and Hougaard, \{David M\} and Elina Hypp├{\^A}nen and Inskip, \{Hazel M\} and Aaron Isaacs and Torben J├{\textcopyright}rgensen and Christina Kanaka-Gantenbein and Kemp, \{John P\} and Wieland Kiess and Kilpel├{\~n}inen, \{Tuomas O\} and Norman Klopp and Knight, \{Bridget A\} and Kuzawa, \{Christopher W\} and George McMahon and Newnham, \{John P\} and Harri Niinikoski and Oostra, \{Ben A\} and Louise Pedersen and Postma, \{Dirkje S\} and Ring, \{Susan M\} and Fernando Rivadeneira and Robertson, \{Neil R\} and Sylvain Sebert and Olli Simell and Torsten Slowinski and Tiesler, \{Carla M T\} and Anke T├{\^A}njes and Allan Vaag and Viikari, \{Jorma S\} and Vink, \{Jacqueline M\} and Vissing, \{Nadja Hawwa\} and Wareham, \{Nicholas J\} and Gonneke Willemsen and Witte, \{Daniel R\} and Haitao Zhang and Jianhua Zhao and Wilson, \{James F\} and Michael Stumvoll and Prentice, \{Andrew M\} and Meyer, \{Brian F\} and Pearson, \{Ewan R\} and Boreham, \{Colin A G\} and Cyrus Cooper and Gillman, \{Matthew W\} and Dedoussis, \{George V\} and Moreno, \{Luis A\} and Oluf Pedersen and Maiju Saarinen and Mohlke, \{Karen L\} and Boomsma, \{Dorret I\} and Seang-Mei Saw and Lakka, \{Timo A\} and Antje K├{\^A}rner and Loos, \{Ruth J F\} and Ong, \{Ken K\} and Peter Vollenweider and \{van Duijn\}, \{Cornelia M\} and Koppelman, \{Gerard H\} and Hattersley, \{Andrew T\} and Holloway, \{John W\} and Berthold Hocher and Joachim Heinrich and Chris Power and Mads Melbye and M├▓nica Guxens and Pennell, \{Craig E\} and Klaus B├{\textcopyright}nnelykke and Hans Bisgaard and Eriksson, \{Johan G\} and Elisabeth Wid├{\textregistered}n and Hakon Hakonarson and Uitterlinden, \{Andr├{\textregistered} G\} and Anneli Pouta and Lawlor, \{Debbie A\} and Smith, \{George Davey\} and Frayling, \{Timothy M\} and McCarthy, \{Mark I\} and Grant, \{Struan F A\} and Jaddoe, \{Vincent W V\} and Marjo-Riitta Jarvelin and Timpson, \{Nicholas J\} and Inga Prokopenko and Freathy, \{Rachel M\} and Momoko Horikoshi and Hennig, \{Branwen J\} and Bradfield, \{Jonathan P\} and \{St Pourcain\}, Beate and Evans, \{David M\} and Pimphen Charoen and Marika Kaakinen and Cousminer, \{Diana L\} and Terho Lehtim├{\~n}ki and Eskil Kreiner-M├{\textcopyright}ller and Warrington, \{Nicole M\} and Mariona Bustamante and Bjarke Feenstra and Berry, \{Diane J\} and Elisabeth Thiering and Hanieh Yaghootkar and Mook-Kanamori, \{Dennis O\} and Ulla Sovio and Taal, \{H Rob\}",

year = "2013",

month = jan,

day = "31",

doi = "10.1038/ng.2477",

language = "English",

volume = "45",

pages = "76--82",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "1",

}

Pfab, T, Barton, SJ, Shields, BM, Kerkhof, M, van Leeuwen, EM, Fulford, AJ, Kutalik, Z, Zhao, JH, den Hoed, M, Mahajan, A, Lindi, V, Goh, L-K, Hottenga, J-J, Wu, Y, Raitakari, OT, Harder, MN, Meirhaeghe, A, Ntalla, I, Salem, RM, Jameson, KA, Zhou, K, Monies, DM, Lagou, V, Kirin, M, Heikkinen, J, Adair, LS, Alkuraya, FS, Al-Odaib, A, Amouyel, P, Andersson, EA, Bennett, AJ, Blakemore, AIF, Buxton, JL, Dallongeville, J, Das, S, de Geus, EJC, Estivill, X, Flexeder, C, Froguel, P, Geller, F, Godfrey, KM, Gottrand, F, Groves, CJ, Hansen, T, Hirschhorn, JN, Hofman, A, Hollegaard, MV, Hougaard, DM, Hypp├Ânen, E, Inskip, HM, Isaacs, A, J├©rgensen, T, Kanaka-Gantenbein, C, Kemp, JP, Kiess, W, Kilpel├ñinen, TO, Klopp, N, Knight, BA, Kuzawa, CW, McMahon, G, Newnham, JP, Niinikoski, H, Oostra, BA, Pedersen, L, Postma, DS, Ring, SM, Rivadeneira, F, Robertson, NR, Sebert, S, Simell, O, Slowinski, T, Tiesler, CMT, T├Ânjes, A, Vaag, A, Viikari, JS, Vink, JM, Vissing, NH, Wareham, NJ, Willemsen, G, Witte, DR, Zhang, H, Zhao, J, Wilson, JF, Stumvoll, M, Prentice, AM, Meyer, BF, Pearson, ER, Boreham, CAG, Cooper, C, Gillman, MW, Dedoussis, GV, Moreno, LA, Pedersen, O, Saarinen, M, Mohlke, KL, Boomsma, DI, Saw, S-M, Lakka, TA, K├Ârner, A, Loos, RJF, Ong, KK, Vollenweider, P, van Duijn, CM, Koppelman, GH, Hattersley, AT, Holloway, JW, Hocher, B, Heinrich, J, Power, C, Melbye, M, Guxens, M, Pennell, CE, B├©nnelykke, K, Bisgaard, H, Eriksson, JG, Wid├®n, E, Hakonarson, H, Uitterlinden, AG, Pouta, A, Lawlor, DA, Smith, GD, Frayling, TM, McCarthy, MI, Grant, SFA, Jaddoe, VWV, Jarvelin, M-R, Timpson, NJ, Prokopenko, I, Freathy, RM, Horikoshi, M, Hennig, BJ, Bradfield, JP, St Pourcain, B, Evans, DM, Charoen, P, Kaakinen, M, Cousminer, DL, Lehtim├ñki, T, Kreiner-M├©ller, E, Warrington, NM, Bustamante, M, Feenstra, B, Berry, DJ, Thiering, E, Yaghootkar, H, Mook-Kanamori, DO, Sovio, U & Taal, HR 2013, 'New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism', Nature Genetics, vol. 45, no. 1, pp. 76-82. https://doi.org/10.1038/ng.2477

TY - JOUR

T1 - New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

AU - Pfab, Thiemo

AU - Barton, Sheila J

AU - Shields, Beverley M

AU - Kerkhof, Marjan

AU - van Leeuwen, Elisabeth M

AU - Fulford, Anthony J

AU - Kutalik, Zolt├ín

AU - Zhao, Jing Hua

AU - den Hoed, Marcel

AU - Mahajan, Anubha

AU - Lindi, Virpi

AU - Goh, Liang-Kee

AU - Hottenga, Jouke-Jan

AU - Wu, Ying

AU - Raitakari, Olli T

AU - Harder, Marie N

AU - Meirhaeghe, Aline

AU - Ntalla, Ioanna

AU - Salem, Rany M

AU - Jameson, Karen A

AU - Zhou, Kaixin

AU - Monies, Dorota M

AU - Lagou, Vasiliki

AU - Kirin, Mirna

AU - Heikkinen, Jani

AU - Adair, Linda S

AU - Alkuraya, Fowzan S

AU - Al-Odaib, Ali

AU - Amouyel, Philippe

AU - Andersson, Ehm Astrid

AU - Bennett, Amanda J

AU - Blakemore, Alexandra I F

AU - Buxton, Jessica L

AU - Dallongeville, Jean

AU - Das, Shikta

AU - de Geus, Eco J C

AU - Estivill, Xavier

AU - Flexeder, Claudia

AU - Froguel, Philippe

AU - Geller, Frank

AU - Godfrey, Keith M

AU - Gottrand, Fr├®d├®ric

AU - Groves, Christopher J

AU - Hansen, Torben

AU - Hirschhorn, Joel N

AU - Hofman, Albert

AU - Hollegaard, Mads V

AU - Hougaard, David M

AU - Hypp├Ânen, Elina

AU - Inskip, Hazel M

AU - Isaacs, Aaron

AU - J├©rgensen, Torben

AU - Kanaka-Gantenbein, Christina

AU - Kemp, John P

AU - Kiess, Wieland

AU - Kilpel├ñinen, Tuomas O

AU - Klopp, Norman

AU - Knight, Bridget A

AU - Kuzawa, Christopher W

AU - McMahon, George

AU - Newnham, John P

AU - Niinikoski, Harri

AU - Oostra, Ben A

AU - Pedersen, Louise

AU - Postma, Dirkje S

AU - Ring, Susan M

AU - Rivadeneira, Fernando

AU - Robertson, Neil R

AU - Sebert, Sylvain

AU - Simell, Olli

AU - Slowinski, Torsten

AU - Tiesler, Carla M T

AU - T├Ânjes, Anke

AU - Vaag, Allan

AU - Viikari, Jorma S

AU - Vink, Jacqueline M

AU - Vissing, Nadja Hawwa

AU - Wareham, Nicholas J

AU - Willemsen, Gonneke

AU - Witte, Daniel R

AU - Zhang, Haitao

AU - Zhao, Jianhua

AU - Wilson, James F

AU - Stumvoll, Michael

AU - Prentice, Andrew M

AU - Meyer, Brian F

AU - Pearson, Ewan R

AU - Boreham, Colin A G

AU - Cooper, Cyrus

AU - Gillman, Matthew W

AU - Dedoussis, George V

AU - Moreno, Luis A

AU - Pedersen, Oluf

AU - Saarinen, Maiju

AU - Mohlke, Karen L

AU - Boomsma, Dorret I

AU - Saw, Seang-Mei

AU - Lakka, Timo A

AU - K├Ârner, Antje

AU - Loos, Ruth J F

AU - Ong, Ken K

AU - Vollenweider, Peter

AU - van Duijn, Cornelia M

AU - Koppelman, Gerard H

AU - Hattersley, Andrew T

AU - Holloway, John W

AU - Hocher, Berthold

AU - Heinrich, Joachim

AU - Power, Chris

AU - Melbye, Mads

AU - Guxens, M├▓nica

AU - Pennell, Craig E

AU - Bisgaard, Hans

AU - Eriksson, Johan G

AU - Wid├®n, Elisabeth

AU - Hakonarson, Hakon

AU - Uitterlinden, Andr├® G

AU - Pouta, Anneli

AU - Lawlor, Debbie A

AU - Smith, George Davey

AU - Frayling, Timothy M

AU - McCarthy, Mark I

AU - Grant, Struan F A

AU - Jaddoe, Vincent W V

AU - Jarvelin, Marjo-Riitta

AU - Timpson, Nicholas J

AU - Prokopenko, Inga

AU - Freathy, Rachel M

AU - Horikoshi, Momoko

AU - Hennig, Branwen J

AU - Bradfield, Jonathan P

AU - St Pourcain, Beate

AU - Evans, David M

AU - Charoen, Pimphen

AU - Kaakinen, Marika

AU - Cousminer, Diana L

AU - Lehtim├ñki, Terho

AU - Warrington, Nicole M

AU - Bustamante, Mariona

AU - Feenstra, Bjarke

AU - Berry, Diane J

AU - Thiering, Elisabeth

AU - Yaghootkar, Hanieh

AU - Mook-Kanamori, Dennis O

AU - Sovio, Ulla

AU - Taal, H Rob

PY - 2013/1/31

Y1 - 2013/1/31

N2 - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

AB - Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.

KW - Biological sciences

U2 - 10.1038/ng.2477

DO - 10.1038/ng.2477

M3 - Article

SN - 1061-4036

VL - 45

SP - 76

EP - 82

JO - Nature Genetics

JF - Nature Genetics

IS - 1

ER -

New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism

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