Novel inhibitors of the enzyme estrone sulfatase (ES)

Sabbir Ahmed; Karen James; Caroline P. Owen; Chirag Patel; Mijal Patel

doi:10.1016/S0960-894X(01)00086-5

Novel inhibitors of the enzyme estrone sulfatase (ES)

Sabbir Ahmed
, Karen James
, Caroline P. Owen
, Chirag Patel
, Mijal Patel

Research output: Contribution to journal › Article › peer-review

Abstract

We report the initial results of our study into a series of simple 4-sulfamated phenyl alkyl ketones as potential inhibitors of the enzyme estrone sulfatase. The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker activity than EMATE. Furthermore, the compounds are observed to be irreversible inhibitors.

Original language	English
Pages (from-to)	841-844
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(01)00086-5
Publication status	Published - 26 Mar 2001

Keywords

aromatase inhibitors
steroid sulfatase
Allied health professions and studies

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10.1016/S0960-894X(01)00086-5

http://dx.doi.org/doi:10.1016/S0960-894X(01)00086-5

Cite this

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title = "Novel inhibitors of the enzyme estrone sulfatase (ES)",

abstract = "We report the initial results of our study into a series of simple 4-sulfamated phenyl alkyl ketones as potential inhibitors of the enzyme estrone sulfatase. The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker activity than EMATE. Furthermore, the compounds are observed to be irreversible inhibitors.",

keywords = "aromatase inhibitors, steroid sulfatase, Allied health professions and studies",

author = "Sabbir Ahmed and Karen James and Owen, \{Caroline P.\} and Chirag Patel and Mijal Patel",

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AU - Ahmed, Sabbir

AU - James, Karen

AU - Owen, Caroline P.

AU - Patel, Chirag

AU - Patel, Mijal

PY - 2001/3/26

Y1 - 2001/3/26

N2 - We report the initial results of our study into a series of simple 4-sulfamated phenyl alkyl ketones as potential inhibitors of the enzyme estrone sulfatase. The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker activity than EMATE. Furthermore, the compounds are observed to be irreversible inhibitors.

AB - We report the initial results of our study into a series of simple 4-sulfamated phenyl alkyl ketones as potential inhibitors of the enzyme estrone sulfatase. The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker activity than EMATE. Furthermore, the compounds are observed to be irreversible inhibitors.

KW - aromatase inhibitors

KW - steroid sulfatase

KW - Allied health professions and studies

UR - http://www.ncbi.nlm.nih.gov/pubmed/11277533

U2 - 10.1016/S0960-894X(01)00086-5

DO - 10.1016/S0960-894X(01)00086-5

M3 - Article

C2 - 11277533

SN - 0960-894X

VL - 11

SP - 841

EP - 844

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Novel inhibitors of the enzyme estrone sulfatase (ES)

Abstract

Keywords

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