Overcoming the protein corona in chitosan-based nanoparticles

Anna E. Caprifico; Peter J.S. Foot; Elena Polycarpou; Gianpiero Calabrese

doi:10.1016/j.drudis.2021.04.014

Overcoming the protein corona in chitosan-based nanoparticles

Anna E. Caprifico
, Peter J.S. Foot
, Elena Polycarpou
, Gianpiero Calabrese

Kingston University

Research output: Contribution to journal › Article › peer-review

Abstract

Numerous properties of chitosan have led to its extensive use in the formulation of nanomaterials for drug delivery. However, the cationic surface of chitosan-based nanoparticles adsorbs proteins upon exposure to biological fluids, forming a phenomenon known as 'protein corona'. This causes several effects such as decreased bioavailability and limited in vivo clinical applications of chitosan nanoparticles. Understanding and overcoming the effects of protein adsorption on chitosan nanoparticles is key for drug delivery purposes. This review focuses on the strategies implemented to increase the stability of chitosan nanoparticles in the systemic circulation by averting the formation of protein corona and the limitations of PEGylation

Original language	English
Pages (from-to)	1825-1840
Journal	Drug Discovery Today
Volume	26
Issue number	8
Early online date	21 Apr 2021
DOIs	https://doi.org/10.1016/j.drudis.2021.04.014
Publication status	Published - 31 Aug 2021

Keywords

Biological sciences

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10.1016/j.drudis.2021.04.014

Calabrese-G-48971-AAMAccepted author manuscript, 503 KBLicence: CC BY-NC-ND

https://doi.org/10.1016/j.drudis.2021.04.014

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abstract = "Numerous properties of chitosan have led to its extensive use in the formulation of nanomaterials for drug delivery. However, the cationic surface of chitosan-based nanoparticles adsorbs proteins upon exposure to biological fluids, forming a phenomenon known as 'protein corona'. This causes several effects such as decreased bioavailability and limited in vivo clinical applications of chitosan nanoparticles. Understanding and overcoming the effects of protein adsorption on chitosan nanoparticles is key for drug delivery purposes. This review focuses on the strategies implemented to increase the stability of chitosan nanoparticles in the systemic circulation by averting the formation of protein corona and the limitations of PEGylation",

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T1 - Overcoming the protein corona in chitosan-based nanoparticles

AU - Caprifico, Anna E.

AU - Foot, Peter J.S.

AU - Polycarpou, Elena

AU - Calabrese, Gianpiero

PY - 2021/8/31

Y1 - 2021/8/31

N2 - Numerous properties of chitosan have led to its extensive use in the formulation of nanomaterials for drug delivery. However, the cationic surface of chitosan-based nanoparticles adsorbs proteins upon exposure to biological fluids, forming a phenomenon known as 'protein corona'. This causes several effects such as decreased bioavailability and limited in vivo clinical applications of chitosan nanoparticles. Understanding and overcoming the effects of protein adsorption on chitosan nanoparticles is key for drug delivery purposes. This review focuses on the strategies implemented to increase the stability of chitosan nanoparticles in the systemic circulation by averting the formation of protein corona and the limitations of PEGylation

AB - Numerous properties of chitosan have led to its extensive use in the formulation of nanomaterials for drug delivery. However, the cationic surface of chitosan-based nanoparticles adsorbs proteins upon exposure to biological fluids, forming a phenomenon known as 'protein corona'. This causes several effects such as decreased bioavailability and limited in vivo clinical applications of chitosan nanoparticles. Understanding and overcoming the effects of protein adsorption on chitosan nanoparticles is key for drug delivery purposes. This review focuses on the strategies implemented to increase the stability of chitosan nanoparticles in the systemic circulation by averting the formation of protein corona and the limitations of PEGylation

KW - Biological sciences

U2 - 10.1016/j.drudis.2021.04.014

DO - 10.1016/j.drudis.2021.04.014

M3 - Article

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VL - 26

SP - 1825

EP - 1840

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 8

ER -

Overcoming the protein corona in chitosan-based nanoparticles

Abstract

Keywords

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