Phe120 contributes to the regiospecificity of cytochrome P450 2D6: Mutation leads to the formation of a novel dextromethorphan metabolite

Jack, U. Flanagan; Jean-Didier Mar├®chal; Richard Ward; Carol, A. Kemp; Lesley, A. McLaughlin; Michael, J. Sutcliffe; Gordon, C.K. Roberts; Mark, J.I. Paine; C. Roland Wolf

doi:10.1042/bj20040062

Phe120 contributes to the regiospecificity of cytochrome P450 2D6: Mutation leads to the formation of a novel dextromethorphan metabolite

Jack, U. Flanagan
, Jean-Didier Mar├®chal
, Richard Ward
, Carol, A. Kemp
, Lesley, A. McLaughlin
, Michael, J. Sutcliffe
, Gordon, C.K. Roberts
, Mark, J.I. Paine
, C. Roland Wolf

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	353-360
Journal	Biochemical Journal
Volume	380
Issue number	2
DOIs	https://doi.org/10.1042/bj20040062
Publication status	Published - Jun 2004
Externally published	Yes

Keywords

Chemistry

Access to Document

10.1042/bj20040062

http://dx.doi.org/10.1042/bj20040062

Cite this

@article{1f9fe7a5f9b144d3883958e584d0d3ab,

title = "Phe120 contributes to the regiospecificity of cytochrome P450 2D6: Mutation leads to the formation of a novel dextromethorphan metabolite",

keywords = "Chemistry",

author = "Flanagan, \{Jack, U.\} and Jean-Didier Mar├{\textregistered}chal and Richard Ward and Kemp, \{Carol, A.\} and McLaughlin, \{Lesley, A.\} and Sutcliffe, \{Michael, J.\} and Roberts, \{Gordon, C.K.\} and Paine, \{Mark, J.I.\} and Wolf, \{C. Roland\}",

year = "2004",

month = jun,

doi = "10.1042/bj20040062",

language = "English",

volume = "380",

pages = "353--360",

journal = "Biochemical Journal",

issn = "0264-6021",

publisher = "Portland Press Ltd",

number = "2",

}

TY - JOUR

T1 - Phe120 contributes to the regiospecificity of cytochrome P450 2D6

T2 - Mutation leads to the formation of a novel dextromethorphan metabolite

AU - Flanagan, Jack, U.

AU - Mar├®chal, Jean-Didier

AU - Ward, Richard

AU - Kemp, Carol, A.

AU - McLaughlin, Lesley, A.

AU - Sutcliffe, Michael, J.

AU - Roberts, Gordon, C.K.

AU - Paine, Mark, J.I.

AU - Wolf, C. Roland

PY - 2004/6

Y1 - 2004/6

KW - Chemistry

U2 - 10.1042/bj20040062

DO - 10.1042/bj20040062

M3 - Article

SN - 0264-6021

VL - 380

SP - 353

EP - 360

JO - Biochemical Journal

JF - Biochemical Journal

IS - 2

ER -