Platelet monoamine oxidase B activity in Parkinson's disease: a re-evaluation

J. Jarman; V. Glover; M. Sandler; N. Turjanski; G. Stern

doi:10.1007/BF02260909

Platelet monoamine oxidase B activity in Parkinson's disease: a re-evaluation

J. Jarman
, V. Glover
, M. Sandler
, N. Turjanski
, G. Stern

Research output: Contribution to journal › Article › peer-review

Abstract

An increase in platelet monoamine oxidase (MAO) B activity in drug-free parkinsonians (n = 6) compared with healthy controls (n = 10) has been confirmed using both phenylethylamine (PEA) and dopamine as substrates, reaching statistical significance in the case of PEA oxidising activity (p < 0.05). Thus, certain reports of raised platelet MAO B activity towards PEA but decreased activity towards dopamine in parkinsonians, raising the possibility of the existence of an abnormal form of MAO B in this condition, cannot be supported.

Original language	English
Pages (from-to)	1-4
Journal	Journal of Neural Transmission - Parkinson's Disease and Dementia Section
Volume	5
Issue number	1
DOIs	https://doi.org/10.1007/BF02260909
Publication status	Published - Feb 1993

Keywords

Biological sciences

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10.1007/BF02260909

http://dx.doi.org/10.1007/BF02260909

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abstract = "An increase in platelet monoamine oxidase (MAO) B activity in drug-free parkinsonians (n = 6) compared with healthy controls (n = 10) has been confirmed using both phenylethylamine (PEA) and dopamine as substrates, reaching statistical significance in the case of PEA oxidising activity (p < 0.05). Thus, certain reports of raised platelet MAO B activity towards PEA but decreased activity towards dopamine in parkinsonians, raising the possibility of the existence of an abnormal form of MAO B in this condition, cannot be supported.",

keywords = "Biological sciences",

author = "J. Jarman and V. Glover and M. Sandler and N. Turjanski and G. Stern",

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AU - Jarman, J.

AU - Glover, V.

AU - Sandler, M.

AU - Turjanski, N.

AU - Stern, G.

PY - 1993/2

Y1 - 1993/2

N2 - An increase in platelet monoamine oxidase (MAO) B activity in drug-free parkinsonians (n = 6) compared with healthy controls (n = 10) has been confirmed using both phenylethylamine (PEA) and dopamine as substrates, reaching statistical significance in the case of PEA oxidising activity (p < 0.05). Thus, certain reports of raised platelet MAO B activity towards PEA but decreased activity towards dopamine in parkinsonians, raising the possibility of the existence of an abnormal form of MAO B in this condition, cannot be supported.

AB - An increase in platelet monoamine oxidase (MAO) B activity in drug-free parkinsonians (n = 6) compared with healthy controls (n = 10) has been confirmed using both phenylethylamine (PEA) and dopamine as substrates, reaching statistical significance in the case of PEA oxidising activity (p < 0.05). Thus, certain reports of raised platelet MAO B activity towards PEA but decreased activity towards dopamine in parkinsonians, raising the possibility of the existence of an abnormal form of MAO B in this condition, cannot be supported.

KW - Biological sciences

UR - http://www.ncbi.nlm.nih.gov/pubmed/8439389

U2 - 10.1007/BF02260909

DO - 10.1007/BF02260909

M3 - Article

C2 - 8439389

SN - 0936-3076

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JO - Journal of Neural Transmission - Parkinson's Disease and Dementia Section

JF - Journal of Neural Transmission - Parkinson's Disease and Dementia Section

IS - 1

ER -

Platelet monoamine oxidase B activity in Parkinson's disease: a re-evaluation

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Keywords

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