Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer: a Qatar based study

Giles Davies; Said Dermime; Shahab Uddin; G. Hossein Ashrafi; Kulsoom Junejo; Rayyan Abdulaziz Fadel; Vinod Kumar Gupta; Ambika Anand; Salahddin Gehani; Sheraz Abayazeed; Omer Al-Yahri; Fakhar Shahid; Salman Alshaibani; Sara Hassan; M. Zafar Chawdhery; Gulab Sher; Nadia Aziz Salman; Michal Kulinski

doi:10.3390/cancers12061528

Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer: a Qatar based study

Giles Davies
, Said Dermime
, Shahab Uddin
, G. Hossein Ashrafi
, Kulsoom Junejo
, Rayyan Abdulaziz Fadel
, Vinod Kumar Gupta
, Ambika Anand
, Salahddin Gehani
, Sheraz Abayazeed
, Omer Al-Yahri
, Fakhar Shahid
, Salman Alshaibani
, Sara Hassan
, M. Zafar Chawdhery
, Gulab Sher
, Nadia Aziz Salman
, Michal Kulinski

Research output: Contribution to journal › Article › peer-review

Abstract

Human papillomavirus (HPV) has been implicated in the etiology of a variety of human cancers. Studies investigating the presence of high-risk (HR) HPV in breast tissue have generated considerable controversy over its role as a potential risk factor for breast cancer (BC). This is the first investigation reporting the prevalence and type distribution of high-risk HPV infection in breast tissue in the population of Qatar. A prospective comparison blind research study herein reconnoitered the presence of twelve HR-HPV types' DNA using multiplex PCR by screening a total of 150 fresh breast tissue specimens. Data obtained shows that HR-HPV types were found in 10% of subjects with breast cancer; of which the presence of HPV was confirmed in 4/33 (12.12%) of invasive carcinomas. These findings, the first reported from the population of Qatar, suggest that the selective presence of HPV in breast tissue is likely to be a related factor in the progression of certain cases of breast cancer.

Original language	English
Article number	1528
Journal	Cancers
Volume	12
Issue number	6
Early online date	10 Jun 2020
DOIs	https://doi.org/10.3390/cancers12061528
Publication status	Published - 10 Jun 2020

Bibliographical note

Note: This work was supported by the Medical Research Centre, Hamad Medical Corporation, Qatar [grant number: 16101/16] and Qatar National Library.

Keywords

Biological sciences
HPV
PCR
Qatar
breast cancer
genotype
prevalence

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10.3390/cancers12061528

Ashrafi-G-H-45740-VoRFinal published version, 576 KBLicence: CC BY

https://doi.org/10.3390/cancers12061528

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Davies, G., Dermime, S., Uddin, S., Ashrafi, G. H., Junejo, K., Fadel, R. A., Gupta, V. K., Anand, A., Gehani, S., Abayazeed, S., Al-Yahri, O., Shahid, F., Alshaibani, S., Hassan, S., Chawdhery, M. Z., Sher, G., Salman, N. A., & Kulinski, M. (2020). Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer: a Qatar based study. Cancers, 12(6), Article 1528. https://doi.org/10.3390/cancers12061528

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title = "Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer: a Qatar based study",

abstract = "Human papillomavirus (HPV) has been implicated in the etiology of a variety of human cancers. Studies investigating the presence of high-risk (HR) HPV in breast tissue have generated considerable controversy over its role as a potential risk factor for breast cancer (BC). This is the first investigation reporting the prevalence and type distribution of high-risk HPV infection in breast tissue in the population of Qatar. A prospective comparison blind research study herein reconnoitered the presence of twelve HR-HPV types' DNA using multiplex PCR by screening a total of 150 fresh breast tissue specimens. Data obtained shows that HR-HPV types were found in 10\% of subjects with breast cancer; of which the presence of HPV was confirmed in 4/33 (12.12\%) of invasive carcinomas. These findings, the first reported from the population of Qatar, suggest that the selective presence of HPV in breast tissue is likely to be a related factor in the progression of certain cases of breast cancer.",

keywords = "Biological sciences, HPV, PCR, Qatar, breast cancer, genotype, prevalence",

author = "Giles Davies and Said Dermime and Shahab Uddin and Ashrafi, \{G. Hossein\} and Kulsoom Junejo and Fadel, \{Rayyan Abdulaziz\} and Gupta, \{Vinod Kumar\} and Ambika Anand and Salahddin Gehani and Sheraz Abayazeed and Omer Al-Yahri and Fakhar Shahid and Salman Alshaibani and Sara Hassan and Chawdhery, \{M. Zafar\} and Gulab Sher and Salman, \{Nadia Aziz\} and Michal Kulinski",

note = "Note: This work was supported by the Medical Research Centre, Hamad Medical Corporation, Qatar [grant number: 16101/16] and Qatar National Library.",

year = "2020",

month = jun,

day = "10",

doi = "10.3390/cancers12061528",

language = "English",

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Davies, G, Dermime, S, Uddin, S, Ashrafi, GH, Junejo, K, Fadel, RA, Gupta, VK, Anand, A, Gehani, S, Abayazeed, S, Al-Yahri, O, Shahid, F, Alshaibani, S, Hassan, S, Chawdhery, MZ, Sher, G, Salman, NA & Kulinski, M 2020, 'Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer: a Qatar based study', Cancers, vol. 12, no. 6, 1528. https://doi.org/10.3390/cancers12061528

TY - JOUR

T1 - Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer

T2 - a Qatar based study

AU - Davies, Giles

AU - Dermime, Said

AU - Uddin, Shahab

AU - Ashrafi, G. Hossein

AU - Junejo, Kulsoom

AU - Fadel, Rayyan Abdulaziz

AU - Gupta, Vinod Kumar

AU - Anand, Ambika

AU - Gehani, Salahddin

AU - Abayazeed, Sheraz

AU - Al-Yahri, Omer

AU - Shahid, Fakhar

AU - Alshaibani, Salman

AU - Hassan, Sara

AU - Chawdhery, M. Zafar

AU - Sher, Gulab

AU - Salman, Nadia Aziz

AU - Kulinski, Michal

N1 - Note: This work was supported by the Medical Research Centre, Hamad Medical Corporation, Qatar [grant number: 16101/16] and Qatar National Library.

PY - 2020/6/10

Y1 - 2020/6/10

N2 - Human papillomavirus (HPV) has been implicated in the etiology of a variety of human cancers. Studies investigating the presence of high-risk (HR) HPV in breast tissue have generated considerable controversy over its role as a potential risk factor for breast cancer (BC). This is the first investigation reporting the prevalence and type distribution of high-risk HPV infection in breast tissue in the population of Qatar. A prospective comparison blind research study herein reconnoitered the presence of twelve HR-HPV types' DNA using multiplex PCR by screening a total of 150 fresh breast tissue specimens. Data obtained shows that HR-HPV types were found in 10% of subjects with breast cancer; of which the presence of HPV was confirmed in 4/33 (12.12%) of invasive carcinomas. These findings, the first reported from the population of Qatar, suggest that the selective presence of HPV in breast tissue is likely to be a related factor in the progression of certain cases of breast cancer.

AB - Human papillomavirus (HPV) has been implicated in the etiology of a variety of human cancers. Studies investigating the presence of high-risk (HR) HPV in breast tissue have generated considerable controversy over its role as a potential risk factor for breast cancer (BC). This is the first investigation reporting the prevalence and type distribution of high-risk HPV infection in breast tissue in the population of Qatar. A prospective comparison blind research study herein reconnoitered the presence of twelve HR-HPV types' DNA using multiplex PCR by screening a total of 150 fresh breast tissue specimens. Data obtained shows that HR-HPV types were found in 10% of subjects with breast cancer; of which the presence of HPV was confirmed in 4/33 (12.12%) of invasive carcinomas. These findings, the first reported from the population of Qatar, suggest that the selective presence of HPV in breast tissue is likely to be a related factor in the progression of certain cases of breast cancer.

KW - Biological sciences

KW - HPV

KW - PCR

KW - Qatar

KW - breast cancer

KW - genotype

KW - prevalence

UR - https://www.mdpi.com/2072-6694/12/6/1528

U2 - 10.3390/cancers12061528

DO - 10.3390/cancers12061528

M3 - Article

SN - 2072-6694

VL - 12

JO - Cancers

JF - Cancers

IS - 6

M1 - 1528

ER -

Prevalence and type distribution of high-risk Human Papillomavirus (HPV) in breast cancer: a Qatar based study

Abstract

Bibliographical note

Keywords

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