Rafoxanide and closantel inhibit SPAK and OSR1 kinases by binding to a highly conserved allosteric site on their C-terminal domains

Mubarak A. AlAmri; Hachemi Kadri; Luke J. Alderwick; Nigel S. Simpkins; Youcef Mehellou

doi:10.1002/cmdc.201700077

Rafoxanide and closantel inhibit SPAK and OSR1 kinases by binding to a highly conserved allosteric site on their C-terminal domains

Mubarak A. AlAmri
, Hachemi Kadri
, Luke J. Alderwick
, Nigel S. Simpkins
, Youcef Mehellou

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	639-645
Journal	ChemMedChem
Volume	12
Issue number	9
Early online date	31 Mar 2017
DOIs	https://doi.org/10.1002/cmdc.201700077
Publication status	Published - 9 May 2017

Bibliographical note

Note: This work was supported by the Medical Research Council [reference: MC_PC_14107].

Keywords

Biological sciences

Access to Document

10.1002/cmdc.201700077

https://doi.org/10.1002/cmdc.201700077

Cite this

@article{35a661520f054cc2b3766e2f861c0e49,

title = "Rafoxanide and closantel inhibit SPAK and OSR1 kinases by binding to a highly conserved allosteric site on their C-terminal domains",

keywords = "Biological sciences",

author = "AlAmri, \{Mubarak A.\} and Hachemi Kadri and Alderwick, \{Luke J.\} and Simpkins, \{Nigel S.\} and Youcef Mehellou",

note = "Note: This work was supported by the Medical Research Council [reference: MC\_PC\_14107].",

year = "2017",

month = may,

day = "9",

doi = "10.1002/cmdc.201700077",

language = "English",

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journal = "ChemMedChem",

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T1 - Rafoxanide and closantel inhibit SPAK and OSR1 kinases by binding to a highly conserved allosteric site on their C-terminal domains

AU - AlAmri, Mubarak A.

AU - Kadri, Hachemi

AU - Alderwick, Luke J.

AU - Simpkins, Nigel S.

AU - Mehellou, Youcef

N1 - Note: This work was supported by the Medical Research Council [reference: MC_PC_14107].

PY - 2017/5/9

Y1 - 2017/5/9

KW - Biological sciences

U2 - 10.1002/cmdc.201700077

DO - 10.1002/cmdc.201700077

M3 - Article

SN - 1860-7179

VL - 12

SP - 639

EP - 645

JO - ChemMedChem

JF - ChemMedChem

IS - 9

ER -