Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration

Dimitra Athanasiou; Monica Aguila; Chikwado A. Opefi; Kieron South; James Bellingham; Dalila Bevilacqua; Peter M. Munro; Naheed Kanuga; Francesca E. Mackenzie; Adam M. Dubis; Anastasios Georgiadis; Anna B. Graca; Rachael A. Pearson; Robin R. Ali; Sanae Sakami; Krzysztof Palczewski; Michael Y. Sherman; Philip J. Reeves; Michael E. Cheetham

doi:10.1093/hmg/ddw387

Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration

Dimitra Athanasiou
, Monica Aguila
, Chikwado A. Opefi
, Kieron South
, James Bellingham
, Dalila Bevilacqua
, Peter M. Munro
, Naheed Kanuga
, Francesca E. Mackenzie
, Adam M. Dubis
, Anastasios Georgiadis
, Anna B. Graca
, Rachael A. Pearson
, Robin R. Ali
, Sanae Sakami
, Krzysztof Palczewski
, Michael Y. Sherman
, Philip J. Reeves
, Michael E. Cheetham

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	305-319
Journal	Human Molecular Genetics
Volume	26
Issue number	2
Early online date	30 Nov 2016
DOIs	https://doi.org/10.1093/hmg/ddw387
Publication status	Published - 15 Jan 2017

Bibliographical note

Note: This work was supported by RP Fighting Blindness [grant numbers: GR580, GR572 and GR563], The BIG Lottery Fund, Fight for Sight, the Wellcome Trust [grant numbers 092621 and 099173], the National Institutes of Health [grant number EY022326] and Arnold and Mabel Beckman Foundation.

Keywords

Biological sciences

Access to Document

10.1093/hmg/ddw387

McKenzie-F-39938-VoRFinal published version, 1.3 MBLicence: CC BY

https://doi.org/10.1093/hmg/ddw387

Cite this

Athanasiou, D., Aguila, M., Opefi, C. A., South, K., Bellingham, J., Bevilacqua, D., Munro, P. M., Kanuga, N., Mackenzie, F. E., Dubis, A. M., Georgiadis, A., Graca, A. B., Pearson, R. A., Ali, R. R., Sakami, S., Palczewski, K., Sherman, M. Y., Reeves, P. J., & Cheetham, M. E. (2017). Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics, 26(2), 305-319. https://doi.org/10.1093/hmg/ddw387

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title = "Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration",

keywords = "Biological sciences",

author = "Dimitra Athanasiou and Monica Aguila and Opefi, \{Chikwado A.\} and Kieron South and James Bellingham and Dalila Bevilacqua and Munro, \{Peter M.\} and Naheed Kanuga and Mackenzie, \{Francesca E.\} and Dubis, \{Adam M.\} and Anastasios Georgiadis and Graca, \{Anna B.\} and Pearson, \{Rachael A.\} and Ali, \{Robin R.\} and Sanae Sakami and Krzysztof Palczewski and Sherman, \{Michael Y.\} and Reeves, \{Philip J.\} and Cheetham, \{Michael E.\}",

note = "Note: This work was supported by RP Fighting Blindness [grant numbers: GR580, GR572 and GR563], The BIG Lottery Fund, Fight for Sight, the Wellcome Trust [grant numbers 092621 and 099173], the National Institutes of Health [grant number EY022326] and Arnold and Mabel Beckman Foundation.",

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doi = "10.1093/hmg/ddw387",

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Athanasiou, D, Aguila, M, Opefi, CA, South, K, Bellingham, J, Bevilacqua, D, Munro, PM, Kanuga, N, Mackenzie, FE, Dubis, AM, Georgiadis, A, Graca, AB, Pearson, RA, Ali, RR, Sakami, S, Palczewski, K, Sherman, MY, Reeves, PJ & Cheetham, ME 2017, 'Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration', Human Molecular Genetics, vol. 26, no. 2, pp. 305-319. https://doi.org/10.1093/hmg/ddw387

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T1 - Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration

AU - Athanasiou, Dimitra

AU - Aguila, Monica

AU - Opefi, Chikwado A.

AU - South, Kieron

AU - Bellingham, James

AU - Bevilacqua, Dalila

AU - Munro, Peter M.

AU - Kanuga, Naheed

AU - Mackenzie, Francesca E.

AU - Dubis, Adam M.

AU - Georgiadis, Anastasios

AU - Graca, Anna B.

AU - Pearson, Rachael A.

AU - Ali, Robin R.

AU - Sakami, Sanae

AU - Palczewski, Krzysztof

AU - Sherman, Michael Y.

AU - Reeves, Philip J.

AU - Cheetham, Michael E.

N1 - Note: This work was supported by RP Fighting Blindness [grant numbers: GR580, GR572 and GR563], The BIG Lottery Fund, Fight for Sight, the Wellcome Trust [grant numbers 092621 and 099173], the National Institutes of Health [grant number EY022326] and Arnold and Mabel Beckman Foundation.

PY - 2017/1/15

Y1 - 2017/1/15

KW - Biological sciences

U2 - 10.1093/hmg/ddw387

DO - 10.1093/hmg/ddw387

M3 - Article

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SN - 0964-6906

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SP - 305

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