Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6

Mark, J.I. Paine; Lesley, A. McLaughlin; Jack, U. Flanagan; Carol, A. Kemp; Michael, J. Sutcliffe; Gordon, C.K. Roberts; C. Roland Wolf

doi:10.1074/jbc.M209519200

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6

Mark, J.I. Paine
, Lesley, A. McLaughlin
, Jack, U. Flanagan
, Carol, A. Kemp
, Michael, J. Sutcliffe
, Gordon, C.K. Roberts
, C. Roland Wolf

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4021-4027
Journal	The Journal of Biological Chemistry
Volume	278
Issue number	6
DOIs	https://doi.org/10.1074/jbc.M209519200
Publication status	Published - Feb 2003
Externally published	Yes

Keywords

Chemistry

Access to Document

10.1074/jbc.M209519200

http://dx.doi.org/10.1074/jbc.M209519200

Cite this

@article{44d32c161166435bb98d7823700e5c95,

title = "Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6",

keywords = "Chemistry",

author = "Paine, \{Mark, J.I.\} and McLaughlin, \{Lesley, A.\} and Flanagan, \{Jack, U.\} and Kemp, \{Carol, A.\} and Sutcliffe, \{Michael, J.\} and Roberts, \{Gordon, C.K.\} and Wolf, \{C. Roland\}",

year = "2003",

month = feb,

doi = "10.1074/jbc.M209519200",

language = "English",

volume = "278",

pages = "4021--4027",

journal = "The Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "6",

}

TY - JOUR

T1 - Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6

AU - Paine, Mark, J.I.

AU - McLaughlin, Lesley, A.

AU - Flanagan, Jack, U.

AU - Kemp, Carol, A.

AU - Sutcliffe, Michael, J.

AU - Roberts, Gordon, C.K.

AU - Wolf, C. Roland

PY - 2003/2

Y1 - 2003/2

KW - Chemistry

U2 - 10.1074/jbc.M209519200

DO - 10.1074/jbc.M209519200

M3 - Article

SN - 0021-9258

VL - 278

SP - 4021

EP - 4027

JO - The Journal of Biological Chemistry

JF - The Journal of Biological Chemistry

IS - 6

ER -