Retinal vasculometry associations with cognition status in UK Biobank

Royce Shakespeare; Alicja R. Rudnicka; Roshan Welikala; Sarah A. Barman; Anthony P. Khawaja; Paul J. Foster; Christopher G. Owen; UK Biobank Eye and Vision Consortium

doi:10.1002/dad2.70087

Retinal vasculometry associations with cognition status in UK Biobank

Royce Shakespeare
, Alicja R. Rudnicka
, Roshan Welikala
, Sarah A. Barman
, Anthony P. Khawaja
, Paul J. Foster
, Christopher G. Owen
, UK Biobank Eye and Vision Consortium

Research output: Contribution to journal › Article › peer-review

Abstract

Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale. One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those < 50 years and venular area among those > 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance.

Original language	English
Article number	e270087
Journal	Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Volume	17
DOIs	https://doi.org/10.1002/dad2.70087
Publication status	Published - 24 Feb 2025

Bibliographical note

Note: The retinal vasculometry work was supported by the Medical Research Council Population and Systems Medicine Board (MR/L02005X/1) and British Heart Foundation (PG/15/101/31889).

Keywords

Cardiovascular medicine

Access to Document

10.1002/dad2.70087

https://doi.org/10.1002/dad2.70087

Cite this

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title = "Retinal vasculometry associations with cognition status in UK Biobank",

abstract = "Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale. One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95\%) participants (mean age 56.6 years, 55.5\% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those < 50 years and venular area among those > 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance.",

keywords = "Cardiovascular medicine",

author = "Royce Shakespeare and Rudnicka, \{Alicja R.\} and Roshan Welikala and Barman, \{Sarah A.\} and Khawaja, \{Anthony P.\} and Foster, \{Paul J.\} and Owen, \{Christopher G.\} and \{UK Biobank Eye and Vision Consortium\}",

note = "Note: The retinal vasculometry work was supported by the Medical Research Council Population and Systems Medicine Board (MR/L02005X/1) and British Heart Foundation (PG/15/101/31889).",

year = "2025",

month = feb,

day = "24",

doi = "10.1002/dad2.70087",

language = "English",

volume = "17",

journal = "Alzheimer's \& Dementia : Diagnosis, Assessment \& Disease Monitoring",

issn = "2352-8729",

publisher = "Wiley",

}

TY - JOUR

T1 - Retinal vasculometry associations with cognition status in UK Biobank

AU - Shakespeare, Royce

AU - Rudnicka, Alicja R.

AU - Welikala, Roshan

AU - Barman, Sarah A.

AU - Khawaja, Anthony P.

AU - Foster, Paul J.

AU - Owen, Christopher G.

AU - UK Biobank Eye and Vision Consortium, null

N1 - Note: The retinal vasculometry work was supported by the Medical Research Council Population and Systems Medicine Board (MR/L02005X/1) and British Heart Foundation (PG/15/101/31889).

PY - 2025/2/24

Y1 - 2025/2/24

N2 - Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale. One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those < 50 years and venular area among those > 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance.

AB - Retinal vasculometry (RV) provides a neurovascular biomarker which may relate to cognitive status. However, the presence and form of association remains unclear and unexamined at scale. One hundred ten thousand two hundred eighty-two retinal images from 63,165 (95%) participants (mean age 56.6 years, 55.5% female) were analyzed. A one SD increase in cognition score was strongly associated with increased arteriolar width, arteriolar tortuosity, increased venular width particularly among those < 50 years and venular area among those > 50 years; also, inversely associated with venular tortuosity, and arteriolar and venular width variance.

KW - Cardiovascular medicine

U2 - 10.1002/dad2.70087

DO - 10.1002/dad2.70087

M3 - Article

SN - 2352-8729

VL - 17

JO - Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

JF - Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

M1 - e270087

ER -

Retinal vasculometry associations with cognition status in UK Biobank

Abstract

Bibliographical note

Keywords

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