Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands

Adam Le Gresley; Ammara Abdullah; Pratchi Desai; Uttam Ghosh; Uma Gollapalli; Munazza Kiran; Shehri Lafon

doi:10.1080/00397911.2010.505703

Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands

Adam Le Gresley
, Ammara Abdullah
, Pratchi Desai
, Uttam Ghosh
, Uma Gollapalli
, Munazza Kiran
, Shehri Lafon

Kingston University

Research output: Contribution to journal › Article › peer-review

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Abstract

The use of the Heck reaction in the synthesis of anthracene-9-monoacrylamide and anthracen-9,10-bisacrylamides as potential G-quadruplex ligands and preliminary biological testing is reported.

Original language	English
Pages (from-to)	2483-2492
Journal	Synthetic Communications
Volume	41
Issue number	16
DOIs	https://doi.org/10.1080/00397911.2010.505703
Publication status	Published - Jun 2010

Keywords

Chemistry
DNA
acrylamide
anthracene
assay
dynamic combinatorial chemistry
g-quadruplex
heck
libraries
small-molecule
telomerase inhibition

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10.1080/00397911.2010.505703

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http://dx.doi.org/10.1080/00397911.2010.505703

Cite this

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title = "Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands",

abstract = "The use of the Heck reaction in the synthesis of anthracene-9-monoacrylamide and anthracen-9,10-bisacrylamides as potential G-quadruplex ligands and preliminary biological testing is reported.",

keywords = "Chemistry, DNA, acrylamide, anthracene, assay, dynamic combinatorial chemistry, g-quadruplex, heck, libraries, small-molecule, telomerase inhibition",

author = "\{Le Gresley\}, Adam and Ammara Abdullah and Pratchi Desai and Uttam Ghosh and Uma Gollapalli and Munazza Kiran and Shehri Lafon",

year = "2010",

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T1 - Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands

AU - Le Gresley, Adam

AU - Abdullah, Ammara

AU - Desai, Pratchi

AU - Ghosh, Uttam

AU - Gollapalli, Uma

AU - Kiran, Munazza

AU - Lafon, Shehri

PY - 2010/6

Y1 - 2010/6

N2 - The use of the Heck reaction in the synthesis of anthracene-9-monoacrylamide and anthracen-9,10-bisacrylamides as potential G-quadruplex ligands and preliminary biological testing is reported.

AB - The use of the Heck reaction in the synthesis of anthracene-9-monoacrylamide and anthracen-9,10-bisacrylamides as potential G-quadruplex ligands and preliminary biological testing is reported.

KW - Chemistry

KW - DNA

KW - acrylamide

KW - anthracene

KW - assay

KW - dynamic combinatorial chemistry

KW - g-quadruplex

KW - heck

KW - libraries

KW - small-molecule

KW - telomerase inhibition

U2 - 10.1080/00397911.2010.505703

DO - 10.1080/00397911.2010.505703

M3 - Article

SN - 0039-7911

VL - 41

SP - 2483

EP - 2492

JO - Synthetic Communications

JF - Synthetic Communications

IS - 16

ER -

Scope of the Heck reaction in the synthesis of of a new family of anthracene diacrylamide G-quadruplex ligands

Abstract

Keywords

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