Abstract
Through whole genome sequence alignments, breakpoints in chromosomal synteny can be identified
and the sequence features associated with these determined. Alignments of the genome sequences of
Neisseria gonorrhoeae strain FA1090, N. gonorrhoeae strain NCCP11945, and N. gonorrhoeae strain
TCDC-NG08107 reveal chromosomal rearrangements that have occurred. Based on these alignments
and dot plot pair-wise comparisons, the overall chromosomal arrangement of strain NCCP11945 and
TCDC-NG08107 are very similar, with no large inversions or translocations. The insertion of the Gonococcal Genetic Island in strain NCCP11945 is the most prominent distinguishing feature differentiating these strains. When strain NCCP11945 is compared to strain FA1090, however, 14 breakpoints in
chromosomal synteny are identified between these gonococcal strains. The majority of these, 11 of 14, are
associated with a prophage, IS elements, or repeat enclosed elements which appear to have played a role
in the rearrangements observed. Additional rearrangements of small regions of the genome are associated
with pilin genes. Although horizontal transfer has played a role in gene acquisition, it is these sequence
features mediating chromosomal rearrangements which appear to be a driving force in the evolution of
diversity within the species
| Original language | English |
|---|---|
| Publication status | Published - 10 Sept 2012 |
| Event | XVIIIth International Pathogenic Neisseria Conference (IPNC) - W├╝rzburg, Germany Duration: 9 Sept 2012 → 14 Sept 2012 |
Conference
| Conference | XVIIIth International Pathogenic Neisseria Conference (IPNC) |
|---|---|
| Period | 9/09/12 → 14/09/12 |
Keywords
- Allied health professions and studies