TY - JOUR
T1 - Signal transduction pathway mutations in gastrointestinal (GI) cancers
T2 - a systematic review and meta-analysis
AU - Tabibzadeh, Alireza
AU - Tameshkel, Fahimeh Safarnezhad
AU - Moradi, Yousef
AU - Soltani, Saber
AU - Moradi-Lakeh, Maziar
AU - Ashrafi, G. Hossein
AU - Motamed, Nima
AU - Zamani, Farhad
AU - Motevalian, Seyed Abbas
AU - Panahi, Mahshid
AU - Esghaei, Maryam
AU - Ajdarkosh, Hossein
AU - Mousavi-Jarrahi, Alireza
AU - Niya, Mohammad Hadi Karbalaie
N1 - Note: This work was supported by the Iran University of Medical Sciences, Tehran, Iran [grant number: 97-275-12664].
PY - 2020/10/30
Y1 - 2020/10/30
N2 - The present study was conducted to evaluate the prevalence of the signaling pathways mutation rate in the Gastrointestinal (GI) tract cancers in a systematic review and meta-analysis study. The study was performed based on the PRISMA criteria. Random models by confidence interval (CI: 95%) were used to calculate the pooled estimate of prevalence via Metaprop command. The pooled prevalence indices of signal transduction pathway mutations in gastric cancer, liver cancer, colorectal cancer, and pancreatic cancer were 5% (95% CI: 3-8%), 12% (95% CI: 8-18%), 17% (95% CI: 14-20%), and 20% (95% CI: 5-41%), respectively. Also, the mutation rates for Wnt pathway and MAPK pathway were calculated to be 23% (95% CI, 14-33%) and 20% (95% CI, 17-24%), respectively. Moreover, the most popular genes were APC (in Wnt pathway), KRAS (in MAPK pathway) and PIK3CA (in PI3K pathway) in the colorectal cancer, pancreatic cancer, and gastric cancer while they were beta-catenin and CTNNB1 in liver cancer. The most altered pathway was Wnt pathway followed by the MAPK pathway. In addition, pancreatic cancer was found to be higher under the pressure of mutation compared with others based on pooled prevalence analysis. Finally, APC mutations in colorectal cancer, KRAS in gastric cancer, and pancreatic cancer were mostly associated gene alterations.
AB - The present study was conducted to evaluate the prevalence of the signaling pathways mutation rate in the Gastrointestinal (GI) tract cancers in a systematic review and meta-analysis study. The study was performed based on the PRISMA criteria. Random models by confidence interval (CI: 95%) were used to calculate the pooled estimate of prevalence via Metaprop command. The pooled prevalence indices of signal transduction pathway mutations in gastric cancer, liver cancer, colorectal cancer, and pancreatic cancer were 5% (95% CI: 3-8%), 12% (95% CI: 8-18%), 17% (95% CI: 14-20%), and 20% (95% CI: 5-41%), respectively. Also, the mutation rates for Wnt pathway and MAPK pathway were calculated to be 23% (95% CI, 14-33%) and 20% (95% CI, 17-24%), respectively. Moreover, the most popular genes were APC (in Wnt pathway), KRAS (in MAPK pathway) and PIK3CA (in PI3K pathway) in the colorectal cancer, pancreatic cancer, and gastric cancer while they were beta-catenin and CTNNB1 in liver cancer. The most altered pathway was Wnt pathway followed by the MAPK pathway. In addition, pancreatic cancer was found to be higher under the pressure of mutation compared with others based on pooled prevalence analysis. Finally, APC mutations in colorectal cancer, KRAS in gastric cancer, and pancreatic cancer were mostly associated gene alterations.
KW - Biological sciences
U2 - 10.1038/s41598-020-73770-1
DO - 10.1038/s41598-020-73770-1
M3 - Article
SN - 2045-2322
VL - 10
JO - Scientific Reports
JF - Scientific Reports
M1 - 18713
ER -