Specific genetic features of 'Campylobacter jejuni' strain G1 revealed by genome sequencing

Andrey Karlyshev; Burhan Lehri; Ana Vieira

doi:10.1093/femsle/fnu064

Specific genetic features of 'Campylobacter jejuni' strain G1 revealed by genome sequencing

Andrey Karlyshev
, Burhan Lehri
, Ana Vieira

Research output: Contribution to journal › Article › peer-review

Abstract

This report describes a draft genome sequence of Campylobacter jejuni strain G1. The strain contains no plasmids, despite being resistant to tetracycline (Tet). Comparison of the genome of this strain with that of a reference strain NCTC 11168 (Tet sensitive) revealed the presence of a candidate gene that may be responsible for antibiotic resistance, as well as the genes involved in the synthesis of ganglioside-mimicking molecules responsible for the development of a neurodegenerative disorder, Guillain-Barré syndrome.

Original language	English
Pages (from-to)	1-3
Journal	FEMS Microbiology Letters
Volume	362
Issue number	4
DOIs	https://doi.org/10.1093/femsle/fnu064
Publication status	Published - Feb 2015

Keywords

tetracycline resistance
multidrug efflux pump
lipo-oligosaccharide
Guillaine-Barre syndrome
ganglioside mimicry
Allied health professions and studies

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10.1093/femsle/fnu064

http://dx.doi.org/10.1093/femsle/fnu064

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abstract = "This report describes a draft genome sequence of Campylobacter jejuni strain G1. The strain contains no plasmids, despite being resistant to tetracycline (Tet). Comparison of the genome of this strain with that of a reference strain NCTC 11168 (Tet sensitive) revealed the presence of a candidate gene that may be responsible for antibiotic resistance, as well as the genes involved in the synthesis of ganglioside-mimicking molecules responsible for the development of a neurodegenerative disorder, Guillain-Barr{\'e} syndrome.",

keywords = "tetracycline resistance, multidrug efflux pump, lipo-oligosaccharide, Guillaine-Barre syndrome, ganglioside mimicry, Allied health professions and studies",

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AB - This report describes a draft genome sequence of Campylobacter jejuni strain G1. The strain contains no plasmids, despite being resistant to tetracycline (Tet). Comparison of the genome of this strain with that of a reference strain NCTC 11168 (Tet sensitive) revealed the presence of a candidate gene that may be responsible for antibiotic resistance, as well as the genes involved in the synthesis of ganglioside-mimicking molecules responsible for the development of a neurodegenerative disorder, Guillain-Barré syndrome.

KW - tetracycline resistance

KW - multidrug efflux pump

KW - lipo-oligosaccharide

KW - Guillaine-Barre syndrome

KW - ganglioside mimicry

KW - Allied health professions and studies

UR - http://www.ncbi.nlm.nih.gov/pubmed/25688069

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EP - 3

JO - FEMS Microbiology Letters

JF - FEMS Microbiology Letters

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ER -

Specific genetic features of 'Campylobacter jejuni' strain G1 revealed by genome sequencing

Abstract

Keywords

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