Synthesis and Biochemical Evaluation of a Range of 2-, 3-and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17 alpha-hydroxylase/17,20-Lyase (P450(17 alpha))

Sabbir Ahmed; Imran Shahid; Kishore Bhatti; Wai-Yee Lee; Caroline Owen

Synthesis and Biochemical Evaluation of a Range of 2-, 3-and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17 alpha-hydroxylase/17,20-Lyase (P450(17 alpha))

Sabbir Ahmed
, Imran Shahid
, Kishore Bhatti
, Wai-Yee Lee
, Caroline Owen

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	524-530
Journal	Letters in Drug Design and Discovery
Volume	6
Issue number	7
Publication status	Published - Oct 2009
Externally published	Yes

Keywords

synthesis
evaluation
probe
enzyme
17 alpha-hydroxylase
17
20-lyase
prostate-cancer
inhibitory-activity
rationalization
cyp17
Biological sciences

Cite this

@article{aa272d35c7ea4076a09cd78487f53655,

title = "Synthesis and Biochemical Evaluation of a Range of 2-, 3-and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17 alpha-hydroxylase/17,20-Lyase (P450(17 alpha))",

keywords = "synthesis, evaluation, probe, enzyme, 17 alpha-hydroxylase, 17, 20-lyase, prostate-cancer, inhibitory-activity, rationalization, cyp17, Biological sciences",

author = "Sabbir Ahmed and Imran Shahid and Kishore Bhatti and Wai-Yee Lee and Caroline Owen",

year = "2009",

month = oct,

language = "English",

volume = "6",

pages = "524--530",

journal = "Letters in Drug Design and Discovery",

issn = "1570-1808",

publisher = "Bentham Science Publishers",

number = "7",

}

Synthesis and Biochemical Evaluation of a Range of 2-, 3-and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17 alpha-hydroxylase/17,20-Lyase (P450(17 alpha)). / Ahmed, Sabbir; Shahid, Imran; Bhatti, Kishore et al.
In: Letters in Drug Design and Discovery, Vol. 6, No. 7, 10.2009, p. 524-530.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and Biochemical Evaluation of a Range of 2-, 3-and 4-Substituted Derivatives of Benzyl Imidazole-Based Compounds as Probes of the Active Site of 17 alpha-hydroxylase/17,20-Lyase (P450(17 alpha))

AU - Ahmed, Sabbir

AU - Shahid, Imran

AU - Bhatti, Kishore

AU - Lee, Wai-Yee

AU - Owen, Caroline

PY - 2009/10

Y1 - 2009/10

KW - synthesis

KW - evaluation

KW - probe

KW - enzyme

KW - 17 alpha-hydroxylase

KW - 17

KW - 20-lyase

KW - prostate-cancer

KW - inhibitory-activity

KW - rationalization

KW - cyp17

KW - Biological sciences

M3 - Article

SN - 1570-1808

VL - 6

SP - 524

EP - 530

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

IS - 7

ER -