Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17 alpha-hydroxylase/17,20-lyase (P-450(17 alpha))

Sabbir Ahmed; Imran Shahid; Sachin Dhanani; Caroline P. Owen

doi:10.1016/j.bmcl.2009.06.070

Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17 alpha-hydroxylase/17,20-lyase (P-450(17 alpha))

Sabbir Ahmed
, Imran Shahid
, Sachin Dhanani
, Caroline P. Owen

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	4698-4701
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	19
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2009.06.070
Publication status	Published - 15 Aug 2009
Externally published	Yes

Keywords

hydroxylase
lyase
prostate cancer
inhibition
sulfonate
p450(17-alpha)
cancer
rationalization
chemotherapy
aromatase
target
Biological sciences

Access to Document

10.1016/j.bmcl.2009.06.070

http://dx.doi.org/doi:10.1016/j.bmcl.2009.06.070

Cite this

@article{0d8a6063a5c7493fa543bc80158c91f3,

title = "Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17 alpha-hydroxylase/17,20-lyase (P-450(17 alpha))",

keywords = "hydroxylase, lyase, prostate cancer, inhibition, sulfonate, p450(17-alpha), cancer, rationalization, chemotherapy, aromatase, target, Biological sciences",

author = "Sabbir Ahmed and Imran Shahid and Sachin Dhanani and Owen, \{Caroline P.\}",

year = "2009",

month = aug,

day = "15",

doi = "10.1016/j.bmcl.2009.06.070",

language = "English",

volume = "19",

pages = "4698--4701",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "16",

}

Ahmed, S, Shahid, I, Dhanani, S & Owen, CP 2009, 'Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17 alpha-hydroxylase/17,20-lyase (P-450(17 alpha))', Bioorganic and Medicinal Chemistry Letters, vol. 19, no. 16, pp. 4698-4701. https://doi.org/10.1016/j.bmcl.2009.06.070

Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17 alpha-hydroxylase/17,20-lyase (P-450(17 alpha)). / Ahmed, Sabbir; Shahid, Imran; Dhanani, Sachin et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 16, 15.08.2009, p. 4698-4701.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17 alpha-hydroxylase/17,20-lyase (P-450(17 alpha))

AU - Ahmed, Sabbir

AU - Shahid, Imran

AU - Dhanani, Sachin

AU - Owen, Caroline P.

PY - 2009/8/15

Y1 - 2009/8/15

KW - hydroxylase

KW - lyase

KW - prostate cancer

KW - inhibition

KW - sulfonate

KW - p450(17-alpha)

KW - cancer

KW - rationalization

KW - chemotherapy

KW - aromatase

KW - target

KW - Biological sciences

U2 - 10.1016/j.bmcl.2009.06.070

DO - 10.1016/j.bmcl.2009.06.070

M3 - Article

SN - 0960-894X

VL - 19

SP - 4698

EP - 4701

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 16

ER -