Synthesis and biochemical evaluation of a series of methanesulfonate derivatives of 4-hydroxyphenyl ketone as probes of the active site of type 3 OF 17[beta]-hydroxysteroid dehydrogenase family of enzymes

Tim Cartledge; Kruti Shah; Moniola S. Olusanjo; Caroline P. Owen; Sabbir Ahmed

doi:10.2174/157018009789108259

Synthesis and biochemical evaluation of a series of methanesulfonate derivatives of 4-hydroxyphenyl ketone as probes of the active site of type 3 OF 17[beta]-hydroxysteroid dehydrogenase family of enzymes

Tim Cartledge, Kruti Shah, Moniola S. Olusanjo, Caroline P. Owen, Sabbir Ahmed

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	518-523
Journal	Letters in Drug Design and Discovery
Volume	6
Issue number	7
DOIs	https://doi.org/10.2174/157018009789108259
Publication status	Published - Oct 2009
Externally published	Yes

Keywords

17 beta-hydroxysteroid dehydrogenase
type 3
androgen ablation
enzyme inhibition
methanesulfonate
potential transition-state
approximate representation
inhibitory-activity
drug design
rationalization
17-beta-hsd3
discovery
Chemistry

Access to Document

10.2174/157018009789108259

http://dx.doi.org/10.2174/157018009789108259

Cite this

Cartledge, T., Shah, K., Olusanjo, M. S., Owen, C. P., & Ahmed, S. (2009). Synthesis and biochemical evaluation of a series of methanesulfonate derivatives of 4-hydroxyphenyl ketone as probes of the active site of type 3 OF 17[beta]-hydroxysteroid dehydrogenase family of enzymes. Letters in Drug Design and Discovery, 6(7), 518-523. https://doi.org/10.2174/157018009789108259

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title = "Synthesis and biochemical evaluation of a series of methanesulfonate derivatives of 4-hydroxyphenyl ketone as probes of the active site of type 3 OF 17[beta]-hydroxysteroid dehydrogenase family of enzymes",

keywords = "17 beta-hydroxysteroid dehydrogenase, type 3, androgen ablation, enzyme inhibition, methanesulfonate, potential transition-state, approximate representation, inhibitory-activity, drug design, rationalization, 17-beta-hsd3, discovery, Chemistry",

author = "Tim Cartledge and Kruti Shah and Olusanjo, \{Moniola S.\} and Owen, \{Caroline P.\} and Sabbir Ahmed",

year = "2009",

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doi = "10.2174/157018009789108259",

language = "English",

volume = "6",

pages = "518--523",

journal = "Letters in Drug Design and Discovery",

issn = "1570-1808",

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Cartledge, T, Shah, K, Olusanjo, MS, Owen, CP & Ahmed, S 2009, 'Synthesis and biochemical evaluation of a series of methanesulfonate derivatives of 4-hydroxyphenyl ketone as probes of the active site of type 3 OF 17[beta]-hydroxysteroid dehydrogenase family of enzymes', Letters in Drug Design and Discovery, vol. 6, no. 7, pp. 518-523. https://doi.org/10.2174/157018009789108259

Synthesis and biochemical evaluation of a series of methanesulfonate derivatives of 4-hydroxyphenyl ketone as probes of the active site of type 3 OF 17[beta]-hydroxysteroid dehydrogenase family of enzymes. / Cartledge, Tim; Shah, Kruti; Olusanjo, Moniola S. et al.
In: Letters in Drug Design and Discovery, Vol. 6, No. 7, 10.2009, p. 518-523.

Research output: Contribution to journal › Article › peer-review

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AU - Shah, Kruti

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AU - Ahmed, Sabbir

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KW - type 3

KW - androgen ablation

KW - enzyme inhibition

KW - methanesulfonate

KW - potential transition-state

KW - approximate representation

KW - inhibitory-activity

KW - drug design

KW - rationalization

KW - 17-beta-hsd3

KW - discovery

KW - Chemistry

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DO - 10.2174/157018009789108259

M3 - Article

SN - 1570-1808

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