Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

Tomris Coban; Cameron Robertson; Sianne Schwikkard; Richard Singer; Adam Legresley

doi:10.1039/D0MD00428F

Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

Tomris Coban
, Cameron Robertson
, Sianne Schwikkard
, Richard Singer
, Adam Legresley

Kingston University

Research output: Contribution to journal › Article › peer-review

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Abstract

The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.

Original language	English
Pages (from-to)	751-757
Journal	RSC Medicinal Chemistry
Volume	5
Early online date	26 Mar 2021
DOIs	https://doi.org/10.1039/D0MD00428F
Publication status	Published - 1 May 2021

Keywords

Chemistry

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10.1039/D0MD00428F

Coban-T-48774-VoRFinal published version, 1.78 MBLicence: CC BY

https://doi.org/10.1039/D0MD00428F

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title = "Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands",

abstract = "The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.",

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author = "Tomris Coban and Cameron Robertson and Sianne Schwikkard and Richard Singer and Adam Legresley",

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doi = "10.1039/D0MD00428F",

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T1 - Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

AU - Coban, Tomris

AU - Robertson, Cameron

AU - Schwikkard, Sianne

AU - Singer, Richard

AU - Legresley, Adam

PY - 2021/5/1

Y1 - 2021/5/1

N2 - The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.

AB - The synthesis of a small number of bis(imino)anthracene derivatives is reported. They were evaluated via NMR for binding efficacy to the G-quadruplex-forming oligonucleotide sequence (TTGGGTT) and show activity against the HeLa cancer cell line. These novel ligands are compared to previously synthesised G-quadruplex ligands that target telomeres and oncogenes.

KW - Chemistry

UR - https://europepmc.org/article/PMC/8152782

U2 - 10.1039/D0MD00428F

DO - 10.1039/D0MD00428F

M3 - Article

SN - 2040-2503

VL - 5

SP - 751

EP - 757

JO - RSC Medicinal Chemistry

JF - RSC Medicinal Chemistry

ER -

Synthesis and evaluation of bis(imino)anthracene derivatives as G-quadruplex ligands

Abstract

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