Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors

Caroline Owen; Mijal Patel; Chirag Patel; Tim Cartledge; Sabbir Ahmed

doi:10.2174/157018007781387773

Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors

Caroline Owen
, Mijal Patel
, Chirag Patel
, Tim Cartledge
, Sabbir Ahmed

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	394-398
Journal	Letters in Drug Design and Discovery
Volume	4
Issue number	6
DOIs	https://doi.org/10.2174/157018007781387773
Publication status	Published - Sept 2007
Externally published	Yes

Keywords

estrone sulfatase
inhibition
breast cancer pk(a)
dibrominated
benzoic acid esters
physicochemical factor
benzoic-acid
derivatives
cancer
Pharmacy

Access to Document

10.2174/157018007781387773

http://dx.doi.org/10.2174/157018007781387773

Cite this

Owen, C., Patel, M., Patel, C., Cartledge, T., & Ahmed, S. (2007). Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors. Letters in Drug Design and Discovery, 4(6), 394-398. https://doi.org/10.2174/157018007781387773

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title = "Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors",

keywords = "estrone sulfatase, inhibition, breast cancer pk(a), dibrominated, benzoic acid esters, physicochemical factor, benzoic-acid, derivatives, cancer, Pharmacy",

author = "Caroline Owen and Mijal Patel and Chirag Patel and Tim Cartledge and Sabbir Ahmed",

year = "2007",

month = sep,

doi = "10.2174/157018007781387773",

language = "English",

volume = "4",

pages = "394--398",

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Owen, C, Patel, M, Patel, C, Cartledge, T & Ahmed, S 2007, 'Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors', Letters in Drug Design and Discovery, vol. 4, no. 6, pp. 394-398. https://doi.org/10.2174/157018007781387773

Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors. / Owen, Caroline; Patel, Mijal; Patel, Chirag et al.
In: Letters in Drug Design and Discovery, Vol. 4, No. 6, 09.2007, p. 394-398.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and in vitro biochemical evaluation of a series of compounds as potential inhibitors of estrone sulfatase (ES) and the role of pK(a) in both the synthesis and the inhibitory activity of the potential inhibitors

AU - Owen, Caroline

AU - Patel, Mijal

AU - Patel, Chirag

AU - Cartledge, Tim

AU - Ahmed, Sabbir

PY - 2007/9

Y1 - 2007/9

KW - estrone sulfatase

KW - inhibition

KW - breast cancer pk(a)

KW - dibrominated

KW - benzoic acid esters

KW - physicochemical factor

KW - benzoic-acid

KW - derivatives

KW - cancer

KW - Pharmacy

U2 - 10.2174/157018007781387773

DO - 10.2174/157018007781387773

M3 - Article

SN - 1570-1808

VL - 4

SP - 394

EP - 398

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

IS - 6

ER -