The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

Gianpiero Calabrese; John J. Nesnas; Eugen Barbu; Dimitris Fatouros; John Tsibouklis

doi:10.1016/j.drudis.2011.09.014

The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

Gianpiero Calabrese, John J. Nesnas, Eugen Barbu, Dimitris Fatouros, John Tsibouklis

Research output: Contribution to journal › Article › peer-review

Abstract

The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of (10)B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action - the subject of this review - is a challenge that is addressed by the development of innovative formulation strategies.

Original language	English
Pages (from-to)	153-159
Journal	Drug Discovery Today
Volume	17
Issue number	3-4
DOIs	https://doi.org/10.1016/j.drudis.2011.09.014
Publication status	Published - Feb 2012

Keywords

Cancer studies

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10.1016/j.drudis.2011.09.014

http://dx.doi.org/10.1016/j.drudis.2011.09.014

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AU - Barbu, Eugen

AU - Fatouros, Dimitris

AU - Tsibouklis, John

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N2 - The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of (10)B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action - the subject of this review - is a challenge that is addressed by the development of innovative formulation strategies.

AB - The early promise of boron neutron capture therapy as a method for the treatment of cancer has been inhibited by the inherent toxicity associated with therapeutically useful doses of (10)B-containing pharmacophores, the need for target-tissue specificity and the challenges imposed by biological barriers. Although developments in the synthetic chemistry of polyhedral boranes have addressed issues of toxicity to a considerable extent, the optimisation of the transport and the delivery of boronated agents to the site of action - the subject of this review - is a challenge that is addressed by the development of innovative formulation strategies.

KW - Cancer studies

UR - http://www.ncbi.nlm.nih.gov/pubmed/21978988

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EP - 159

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 3-4

ER -

The formulation of polyhedral boranes for the boron neutron capture therapy of cancer

Abstract

Keywords

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