TY - JOUR
T1 - The use of albumin solid dispersion to enhance the solubility of unionisable drugs
AU - Khoder, Mouhamad
AU - Abdelkader, Hamdy
AU - ElShaer, Amr
AU - Karam, Ayman
AU - Najlah, Mohammad
AU - Alany, Raid G.
PY - 2018
Y1 - 2018
N2 - In this study, solid dispersions of prednisolone (PRD) and bovine serum albumin (BSA) were prepared by spray drying and freeze drying methods using a PRD:BSA solution [20:1 molar ratio (MR)]. PRD-BSA dispersed mixtures were characterized by scanning electron microscopy (SEM), and powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC). PRD-BSA physical and dispersed mixtures showed significantly higher solubility in water than that of unprocessed drug. Enhancement factor of six was obtained in both physical mixture and solid dispersion solubility studies. In-vitro dissolution and release studies under physiological conditions showed an immediate release of PRD from the solid dispersions, with almost 90% of the drug dissolved in the first 10 min. PRD was immediately released from BSA binding complex. This study demonstrates the potential for the use of BSA to enhance the solubility and dissolution rate, hence bioavailability, of the unionizable drugs.
AB - In this study, solid dispersions of prednisolone (PRD) and bovine serum albumin (BSA) were prepared by spray drying and freeze drying methods using a PRD:BSA solution [20:1 molar ratio (MR)]. PRD-BSA dispersed mixtures were characterized by scanning electron microscopy (SEM), and powder X-ray diffraction (XRD), and differential scanning calorimetry (DSC). PRD-BSA physical and dispersed mixtures showed significantly higher solubility in water than that of unprocessed drug. Enhancement factor of six was obtained in both physical mixture and solid dispersion solubility studies. In-vitro dissolution and release studies under physiological conditions showed an immediate release of PRD from the solid dispersions, with almost 90% of the drug dissolved in the first 10 min. PRD was immediately released from BSA binding complex. This study demonstrates the potential for the use of BSA to enhance the solubility and dissolution rate, hence bioavailability, of the unionizable drugs.
KW - Pharmacy
UR - https://www.ncbi.nlm.nih.gov/pubmed/28771055
UR - http://www.tandfonline.com/doi/abs/10.1080/10837450.2017.1364267
U2 - 10.1080/10837450.2017.1364267
DO - 10.1080/10837450.2017.1364267
M3 - Article
C2 - 28771055
SN - 1083-7450
VL - 23
SP - 732
EP - 738
JO - Pharmaceutical Development and Technology
JF - Pharmaceutical Development and Technology
IS - 7
ER -