Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines

Patrick Kielty; Pau Farras; Patrick McArdle; Dennis A. Smith; Fawaz Aldabbagh

doi:10.1039/C9CC08261A

Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines

Patrick Kielty
, Pau Farras
, Patrick McArdle
, Dennis A. Smith
, Fawaz Aldabbagh

Research output: Contribution to journal › Article › peer-review

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Original language	English
Pages (from-to)	14665-14668
Journal	Chemical Communications
Volume	55
Issue number	97
Early online date	14 Nov 2019
DOIs	https://doi.org/10.1039/C9CC08261A
Publication status	Published - 18 Dec 2019

Bibliographical note

Impact: Disclosed is an alternative to bioreductive unmasking of methides, using controllable soft visible-light release of nitroxides from alkoxyamines. We envisage wide-ranging applications from this new class of photoactive molecules from visible-light activated cytotoxins to radical initiators for vinyl monomer photopolymerization with the possibility of forming polymers end-functionalized with antibiotics.

Keywords

Cancer studies
anti-cancer
nitroxides
radicals
trapping

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10.1039/C9CC08261ALicence: CC BY

Aldabbagh-F-44436-VoRFinal published version, 2.35 MBLicence: CC BY

Correction: Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines
Kielty, P., Farràs, P., McArdle, P., Smith, D. A. & Aldabbagh, F., 11 Oct 2020, In: Chemical Communications. 79, 11891.
Research output: Contribution to journal › Article › peer-review

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title = "Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines",

keywords = "Cancer studies, anti-cancer, nitroxides, radicals, trapping",

author = "Patrick Kielty and Pau Farras and Patrick McArdle and Smith, \{Dennis A.\} and Fawaz Aldabbagh",

note = "Impact: Disclosed is an alternative to bioreductive unmasking of methides, using controllable soft visible-light release of nitroxides from alkoxyamines. We envisage wide-ranging applications from this new class of photoactive molecules from visible-light activated cytotoxins to radical initiators for vinyl monomer photopolymerization with the possibility of forming polymers end-functionalized with antibiotics.",

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AU - Kielty, Patrick

AU - Farras, Pau

AU - McArdle, Patrick

AU - Smith, Dennis A.

AU - Aldabbagh, Fawaz

N1 - Impact: Disclosed is an alternative to bioreductive unmasking of methides, using controllable soft visible-light release of nitroxides from alkoxyamines. We envisage wide-ranging applications from this new class of photoactive molecules from visible-light activated cytotoxins to radical initiators for vinyl monomer photopolymerization with the possibility of forming polymers end-functionalized with antibiotics.

PY - 2019/12/18

Y1 - 2019/12/18

KW - Cancer studies

KW - anti-cancer

KW - nitroxides

KW - radicals

KW - trapping

U2 - 10.1039/C9CC08261A

DO - 10.1039/C9CC08261A

M3 - Article

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VL - 55

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EP - 14668

JO - Chemical Communications

JF - Chemical Communications

IS - 97

ER -

Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines

Bibliographical note

Keywords

Access to Document

Research output

Correction: Visible-light unmasking of heterocyclic quinone methide radicals from alkoxyamines

Cite this