Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding

Lesley, A. McLaughlin; Mark, J.I. Paine; Carol, A. Kemp; Jean-Didier Mar├®chal; Jack, U. Flanagan; Clive, J. Ward; Michael, J. Sutcliffe; Gordon, C.K. Roberts; C. Roland Wolf

doi:10.1074/jbc.M505974200

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding

Lesley, A. McLaughlin
, Mark, J.I. Paine
, Carol, A. Kemp
, Jean-Didier Mar├®chal
, Jack, U. Flanagan
, Clive, J. Ward
, Michael, J. Sutcliffe
, Gordon, C.K. Roberts
, C. Roland Wolf

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	38617-38624
Journal	The Journal of Biological Chemistry
Volume	280
Issue number	46
DOIs	https://doi.org/10.1074/jbc.M505974200
Publication status	Published - Nov 2005
Externally published	Yes

Keywords

Chemistry

Access to Document

10.1074/jbc.M505974200

http://dx.doi.org/10.1074/jbc.M505974200

Cite this

@article{c61364bc683b4025ad4b5e487cf929bb,

title = "Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding",

keywords = "Chemistry",

author = "McLaughlin, \{Lesley, A.\} and Paine, \{Mark, J.I.\} and Kemp, \{Carol, A.\} and Jean-Didier Mar├{\textregistered}chal and Flanagan, \{Jack, U.\} and Ward, \{Clive, J.\} and Sutcliffe, \{Michael, J.\} and Roberts, \{Gordon, C.K.\} and Wolf, \{C. Roland\}",

year = "2005",

month = nov,

doi = "10.1074/jbc.M505974200",

language = "English",

volume = "280",

pages = "38617--38624",

journal = "The Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "46",

}

TY - JOUR

T1 - Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding

AU - McLaughlin, Lesley, A.

AU - Paine, Mark, J.I.

AU - Kemp, Carol, A.

AU - Mar├®chal, Jean-Didier

AU - Flanagan, Jack, U.

AU - Ward, Clive, J.

AU - Sutcliffe, Michael, J.

AU - Roberts, Gordon, C.K.

AU - Wolf, C. Roland

PY - 2005/11

Y1 - 2005/11

KW - Chemistry

U2 - 10.1074/jbc.M505974200

DO - 10.1074/jbc.M505974200

M3 - Article

SN - 0021-9258

VL - 280

SP - 38617

EP - 38624

JO - The Journal of Biological Chemistry

JF - The Journal of Biological Chemistry

IS - 46

ER -